RUI: Nanoparticle Film Assemblies: Interfaces for Controlling the Nanoscale Adsorption Environment and Electrochemical Behavior of Immobilized Redox Proteins

RUI：纳米颗粒薄膜组件：用于控制固定化氧化还原蛋白的纳米级吸附环境和电化学行为的界面

• 批准号: 0847145
• 负责人: Michael Leopold
• 金额: $ 25.5万
• 依托单位: University of Richmond
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-15 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847145&HistoricalAwards=false
• 关键词: RUI; Nanoparticle; Film; Assemblies; Interfaces; RUI; Nanoparticle; Film; Assemblies; Interfaces

Professor Michael C. Leopold of the University of Richmond is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to conduct research leading to the development of chemically modified gold nanoparticles assembled onto conducting surfaces, known as monolayer-protected clusters (MPCs), and to use this platform as a functional electrode component for protein monolayer electrochemistry to probe the electron transfer properties of immobilized redox proteins, while preserving their biological function. Experiments will be conducted to study the role of the core size and functionality of the MPCs, and the dependence of electron transfer rates on distance through the MPCs. Understanding of the interactions and charge transfer properties of proteins with these substrates will lead to a better realization of the potential of MPCs in many applications in bioanalytical chemistry leading to the development of miniaturized biosensors. This research will involve undergraduate students in an undergraduate institution in modern research methods and train them in state-of-the-art instrumentation.

里士满大学的迈克尔·C·利奥波德（Michael C.氧化还原蛋白，同时保留其生物学功能。 将进行实验以研究MPC的核心大小和功能的作用，以及电子传递速率对通过MPC的距离的依赖性。 了解蛋白质与这些底物的相互作用和电荷转移特性将使MPC在生物分析化学中的许多应用中的潜力更好地实现，从而导致微型生物传感器的发展。 这项研究将涉及本科生的本科生，从事现代研究方法，并以最先进的仪器进行培训。