Collaborative Research: Biologically Inspired Robotic Microswimmers

合作研究：仿生机器人微型游泳者

• 批准号: 0828239
• 负责人: Kenneth Breuer
• 金额: $ 24.65万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0828239&HistoricalAwards=false
• 关键词: Collaborative; Research; Biologically; Inspired; Robotic

CBET-0828239BreuerBacterial flagellar propulsion represents an extraordinary system in nature for generating motion at the micrometer scale due to their unique molecular polymeric structure adapting to different shapes, depending on the local chemical and flow conditions. Their motion induces a local flow that can be used to propel cells, as well as much larger structures through a fluid environment. This collaborative research team plans to understand, to model and to exploit the physics of flagellar propulsion for use in engineered microfluidic systems. The objective of the program is to understand the fundamental scientific principles that govern the assembly and operation of flagellar-propelled devices (both single swimmers and collectively-powered devices), as well as to demonstrate the enabling technologies necessary to harness polymeric protein nanostructures such as bacterial flagellar filaments on microstructures for use in micron-scale engineered propulsion systems. This collaborative proposal between Drexel University and Brown University is the first to focus on the specific characteristics associated with the polymorphic transformation of bacterial flagellar filaments to demonstrate the ability to move larger engineered elements through a microfluidic landscape in a controlled and directed manner. Fundamental scientific merits addressed by this proposal include using nanoscale flagellar filaments in engineered systems for micron-scale propulsion. Basic questions are to be answered regarding the mechanisms leading to self-coordination of flagellar filaments in responses to a variety of external stimuli. Possible coordination of flagellar filaments to transport microstructures in various microfluidic environments will be examined, thus enabling an entirely new class of swimming robotic systems with applications to bio-engineered actuators, drug delivery systems, and machines for micron-scale transport and assembly. Demonstration of the control of bacterial flagellar filaments at micro- and nanoscales and the ability to integration information technology with bio and nanotechnology will have great impact. The program will have an intensive outreach component, including active recruitment and training of women and underrepresented minorities engineers leveraging and expanding existing and proven programs already in place at Brown and Drexel and outreach to inner-city high school student and teacher populations in both Providence and Philadelphia through the BROWNOUT (Brown) and INSPIRE (Drexel) programs. These enable in-classroom training and teacher-in-residence programs at the university campuses.

CBET-0828239BREERUEREERERUERERUERERERAILAIL鞭毛推进代表了一种本质上的非凡系统，该系统是在微米尺度上产生运动的非凡系统，因为它们的独特分子聚合物结构可适应不同的形状，具体取决于局部化学和流动条件。它们的运动诱导可用于通过流体环境推动细胞以及更大的结构的局部流动。这个协作研究团队计划理解，建模和利用鞭毛推进物理，以用于工程的微流体系统。该计划的目的是了解控制鞭毛式设备的组装和运行的基本科学原则（既有单个游泳者和集体供电的设备），并证明了利用聚合物蛋白质纳米结构所必需的有能力的技术，例如细菌型鞭毛型鞭毛型镀金型在微观型系统上，以实现微米的使用。德雷克塞尔大学与布朗大学之间的这一合作提议是第一个关注与细菌鞭毛细丝的多态性转化相关的特定特征，以证明以受控和定向的方式通过微流体景观移动更大的工程元素。该提案所针对的基本科学优点包括在微米级推进的工程系统中使用纳米级鞭毛细丝。关于导致鞭毛细丝的自我协调的机制，应回答基本问题，以回应各种外部刺激。 将检查鞭毛细丝以在各种微流体环境中运输微观结构的可能协调，从而使一类全新的游泳机器人系统适用于生物工程的执行器，药物输送系统，药物输送系统和微米尺度运输和组装的机器。证明了微观和纳米级细菌鞭毛细丝的控制以及将信息技术与生物和纳米技术集成的能力将产生很大的影响。该计划将具有密集的外展成分，包括对妇女的积极招募和培训以及代表性不足的少数群体工程师，通过在Brown和Drexel的现有和扩大现有的和验证的计划，以及向市区高中学生和教师宣传在Providence和Providence和Philadelphia中通过BrownOut（Brown）以及Inspire（Drexel）计划。这些可以在大学校园内进行课堂内培训和居住课程。