Genetic Analysis of Behavioral Variation Among Wild and Domesticated Strains of Zebrafish.

野生和驯化斑马鱼品系行为变异的遗传分析。

• 批准号: 0818904
• 负责人: Barrie Robison
• 金额: $ 42.69万
• 依托单位: Regents of the University of Idaho
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0818904&HistoricalAwards=false
• 关键词: Genetic; Analysis; Behavioral; Variation; Among

The process of animal domestication often causes profound changes in fear-related behaviors, with domesticated populations becoming substantially less fearful than their wild ancestors. The evolution of reduced fearfulness occurs in numerous domesticated vertebrates, including birds, mammals, and fish, but very little is known about the genetic changes that drive this process. Are the genetic changes that occur during domestication always the same, or are there many different genetic paths leading to the same behavioral outcome? To address this question, researchers must first identify the genes that regulate fear related behaviors in vertebrates. The proposed research uses genetic techniques to identify the genes that are responsible for differences in fear-related behaviors among wild and domesticated populations of zebrafish. In addition to being an important biomedical model, the zebrafish is also emerging as a powerful model in behavior genetics. The results of this research will be important in many contexts, including the study of molecular mechanisms of behavioral evolution, the genetic basis of complex behaviors, and the effective conservation of captively reared species. Broader impacts: The issue of captive rearing is particularly relevant to the Native American tribes of Idaho and the Northwest because of the Tribe's close economic and cultural ties to salmon fisheries. To increase participation of Native American Students in the sciences, this research program will host two Native American high school students in the lab each summer.

动物驯化过程常常会导致与恐惧相关的行为发生深刻的变化，驯化动物的恐惧程度大大低于其野生祖先。 减少恐惧感的进化发生在许多驯化脊椎动物中，包括鸟类、哺乳动物和鱼类，但人们对驱动这一过程的基因变化知之甚少。驯化过程中发生的遗传变化是否总是相同，或者是否有许多不同的遗传路径导致相同的行为结果？为了解决这个问题，研究人员必须首先确定调节脊椎动物恐惧相关行为的基因。拟议的研究利用遗传技术来识别导致野生和驯化斑马鱼种群中恐惧相关行为差异的基因。 除了成为重要的生物医学模型之外，斑马鱼也正在成为行为遗传学领域的强大模型。 这项研究的结果在许多方面都很重要，包括行为进化的分子机制、复杂行为的遗传基础以及圈养物种的有效保护等研究。 更广泛的影响：圈养饲养问题与爱达荷州和西北地区的美洲原住民部落尤其相关，因为该部落与鲑鱼渔业有着密切的经济和文化联系。 为了增加美国原住民学生对科学的参与，该研究项目每年夏天都会在实验室接待两名美国原住民高中生。