III-CXT-Large: Collaborative Research: Interactive and intelligent searching of biological images by query and network navigation with learning capabilities

III-CXT-Large：协作研究：通过具有学习能力的查询和网络导航对生物图像进行交互式和智能搜索

• 批准号: 0808770
• 负责人: Eamonn Keogh
• 金额: $ 110.91万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0808770&HistoricalAwards=false
• 关键词: III; CXT; Large; Collaborative; Research

A fundamental and hard question in biology is identification of organisms. This proposal focuses on identification of nematodes, which are particularly difficult to identify, with the average identification requiring significant time and high level of expertise. Nematodes have direct and significant effect on humans, other animals, and agriculture. Four species of nematode parasites infect over 2 billion people worldwide, and one type of nematode causes one-third of the total estimated worldwide annual yield losses to all soybean pathogens. The current limiting factors for identification are the lack of tools and automation, the need for image comparison off-line and a need for significant expertise. To enable seasoned researchers as well as students to use resources, the team will build on image searching work, using a set of images that will make nematode identification a simple process of point and click. In addition to enabling research by harnessing data and experience of experts, the work may make biology more accessible. The team will build a computer-assisted interactive navigator that will intelligently assist and learn from the user. The work can be extended to many other biological data sets. The research challenges include extraction of features and similarity functions, and the mining, clustering, and anomaly detection for image and non-image data. Graduate students are engaged in the research and outreach involving high school students is also planned.

生物学中的一个基本且困难的问题是生物体的识别。 该提案的重点是线虫的鉴定，线虫的鉴定特别困难，平均鉴定需要大量时间和高水平的专业知识。 线虫对人类、其他动物和农业有直接而重大的影响。 四种线虫寄生虫感染了全世界超过 20 亿人，其中一种线虫导致了全球所有大豆病原体估计年产量损失总额的三分之一。 当前识别的限制因素是缺乏工具和自动化、需要离线图像比较以及需要大量专业知识。 为了让经验丰富的研究人员和学生能够使用资源，该团队将在图像搜索工作的基础上，使用一组图像，使线虫识别成为一个简单的点击过程。 除了通过利用专家的数据和经验进行研究之外，这项工作还可以使生物学变得更容易理解。 该团队将构建一个计算机辅助交互式导航器，它将智能地帮助用户并向用户学习。 这项工作可以扩展到许多其他生物数据集。 研究挑战包括特征和相似函数的提取，以及图像和非图像数据的挖掘、聚类和异常检测。 研究生正在参与研究，还计划让高中生参与研究。