Surace Engineered Carbon Electrodes for Biosensor Arrays

用于生物传感器阵列的 Surace 工程碳电极

• 批准号: 0800525
• 负责人: Chunlei Wang
• 金额: $ 25万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-15 至 2012-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0800525&HistoricalAwards=false
• 关键词: Surace; Engineered; Carbon; Electrodes; Biosensor

In order to develop highly reproducible, highly selective, and miniaturized sensitive electrical DNA sensing platform, it is important to develop and study sensor-biological interface that is compatible with microfabrication processing and also provide the requisite sensitivity and stability when exposed to biological environments. Recent developments in Carbon-MicroElectroMechanical Systems and Carbon-NanoElectroMechanical Systems have led to simple fabrication techniques that result in novel micro/nano-scale carbon structures with high-aspect-ratio and high surface area. The research objective of this award is to advance fundamental research in the use of pyrolyzed carbon as a bio-sensing electrode material by testing and engineering various types of carbon electrodes with high surface areas and different arrangements, developing methods of increasing the surface immobilization efficiency of bio molecules, engineering techniques for bio molecules immobilization on polymer/carbon interfaces, and further understanding fundamental chemical and electrochemical phenomena occurring at or near bio/carbon or bio/polymer/carbon interfaces. If successful, the results of this research will provide an opportunity to create next generation highly sensitive and highly selective inexpensive portable biosensors. This research will broaden the participation of women and minority students in science and engineering, and also foster interdisciplinary interactions with students (especially Hispanic minority students). The research results will be broadly disseminated to enhance scientific and technological understanding through presentation at conferences and publication in journals. In this project, we will effect graduate and undergraduate education and try to raise the awareness in state-of-arts MEMS device and biotechnology for elementary and high school students in local area. Newly developed technique will be highlighted in graduate courses.

为了开发高度可重现，高度选择性和微型敏感的敏感电DNA感应平台，开发和研究传感器生物学界面非常重要，这些接口与微型制作处理兼容，并在暴露于生物学环境时提供必要的灵敏度和稳定性。碳微型机电系统和碳纳米机电系统的最新发展导致了简单的制造技术，从而导致新型的微/纳米尺度碳结构具有高敏感性和高表面积和高表面积。该奖项的研究目的是通过测试和工程进行高表面积和不同排列的各种类型的碳电极来提高基础研究，以使用焦化碳作为生物感应电极材料，并开发了提高生物分子的表面固定效率的方法电化学现象发生在生物/碳或生物/聚合物/碳界面。如果成功，这项研究的结果将为创建下一代高度敏感且高度廉价的便携式生物传感器提供机会。这项研究将扩大妇女和少数民族学生参与科学和工程学，并促进与学生（尤其是西班牙裔少数民族学生）的跨学科互动。研究结果将被广泛传播，以通过在期刊上的会议和出版物上的介绍来增强科学和技术理解。在这个项目中，我们将影响研究生和本科教育，并试图提高对当地的小学和高中生的最先进的MEMS设备和生物技术的认识。新开发的技术将在研究生课程中突出显示。