Dynamic Nuclear Polarization: Integrating fundamentals and new applications

动态核极化：整合基础知识和新应用

• 批准号: 185440219
• 负责人: Professor Dr. Hartmut Oschkinat
• 金额: --
• 依托单位: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
• 依托单位国家: 德国
• 项目类别: DIP Programme
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/185440219?language=en
• 关键词: Dynamic; Nuclear; Polarization; Integrating; fundamentals

NMR and MRI are witnessing a revolution, being driven by the advent of dynamic nuclear polarization (DNP), which promises to increase their sensitivity by several orders of magnitude by transferring the much larger polarization of electron spins to nuclear spins. This proposal put forward a unique collaborative effort of leading magnetic resonance laboratories deeply involved in these exciting developments with expertise in NMR and EPR (electron paramagnetic resonance) basic spin physics, instrumental developments and materials research to biomolecular and preclinical NMR and MRI investigations. The global aims of the present DIP proposal are to investigate the spin dynamics occurring in the three DNP settings (liquid, solids and dissolution) thereby clarifying the various mechanisms underlying the DNP effect. Then, to use this new understanding to obtain the optimum transfer conditions yielding maximum NMR/MRI signal enhancements, exploiting the new opportunities that these developments can open in Chemistry, Biology and Medicine, and finally utilize all this collective knowledge to create on the next generation of DNP polarizers. Specific tasks include:(1) Develop the quantum mechanical framework needed to understand the different aspects of the electron-nuclear and nuclear-nuclear interactions that come to play in the various DNP scenarios. This will rely heavily on systematic experiments isolating the effect of the various parameters DNP depends on. (2) Develop new experimental protocols for optimizing the information frontiers opened up by DNP. (3) Exploit the theoretical and experimental know-how derived from points #1 and #2, to develop the next generation of both in situ and ex situ DNP instruments. (4) Feed back the new insight gained in points #1-through-#3 above, both into the theory of DNP as well as into the development of a new series of experimental applications geared at both solid-state high resolution chemical and biological studies. We believe that this program carries the promise to shape all DNP-related research and its applications.

NMR和MRI目睹了一场革命，这是由动态核极化（DNP）的出现驱动的，该革命有望通过将电子旋转更大的极化转移到核自旋上，从而通过多个数量级来提高其灵敏度。该提案提出了一项独特的合作努力，即领先的磁共振实验室深深地参与了这些令人兴奋的发展，并在NMR和EPR（电子顺磁性共鸣）方面具有专业知识（基本的旋转物理学，工具开发和材料研究），对生物分子和临床前NMR和MRI研究。当前倾斜提案的全球目的是研究在三种DNP设置（液体，固体和溶解）中发生的自旋动力学，从而阐明DNP效应的各种机制。然后，要利用这种新的理解来获得最佳的转移条件，从而获得最大的NMR/MRI信号增强功能，利用这些发展可以在化学，生物学和医学中开放的新机会，最后利用所有这些集体知识来创建下一代DNP极化器的。特定任务包括：（1）开发理解在各种DNP场景中播放的电子核和核核相互作用的不同方面所需的量子机械框架。这将在很大程度上依赖于隔离各种参数DNP的效果的系统实验。 （2）开发新的实验协议，以优化DNP打开的信息边界。 （3）利用从点＃1和2得出的理论和实验性知识，以开发下一代原位和原位DNP仪器。 （4）回馈上面的第1点＃3点获得的新见解，均以DNP理论以及针对固态高分辨率化学和生物学的新系列实验应用的开发。研究。我们认为，该计划具有塑造所有与DNP相关的研究及其应用的承诺。