MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutants

MRI：采购气相色谱仪器，用于分析新的和新兴的令人关注的化学品和遗留污染物的研究和高级培训

• 批准号: 0722861
• 负责人: Michael Milligan
• 金额: $ 15.69万
• 依托单位: SUNY College at Fredonia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0722861&HistoricalAwards=false
• 关键词: MRI; Acquisition; gas; chromatographic; instrumentation

Proposal: 0722861PI: Michael S MilliganInstitution: SUNY College at FredoniaTitle: MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutantsThis work augments a cross-campus collaboration at two primarily undergraduate institutions, the State University of New York (SUNY) at Fredonia and SUNY at Oswego. The Principal Investigator at SUNY Fredonia (Michael S. Milligan, Department of Chemistry and Biochemistry) and the Co-Principal Investigator at SUNY Oswego (James J. Pagano, Department of Chemistry and the Environmental Research Center) have successfully collaborated in numerous funded and non-funded research projects over the past ten years that have led to many student co-authored publications and conference abstracts. Both the PI and the Co-PI supervise modern analytical laboratories dedicated to sample extraction, clean-up, and analysis of organic contaminants. Through the acquisition of three gas chromatographs: one with updated and modernized mass selective detection (including electron impact, positive ion chemical ionization, and negative ion chemical ionization sources) and two with electron capture detection capabilities, the PI and Co-PI will further enhance their expertise in the analysis of new and emerging chemical compounds of concern, endocrine system disrupting compounds such as chlorinated dioxins/furans (PCDD/Fs) and co-planar polychlorinated biphenyls (PCBs), and legacy pollutants such as PCBs, polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides found in atmospheric samples, Great Lakes fish, and other environmental media. The intellectual merit of this project involves the development, advancement, and refinement of trace analytical techniques used for the detection and quantification of organic contaminants. These types of analytical challenges often demand sub-picogram and sub-part per billion (ppb) detection limits, and require sophisticated instrumentation for success. The PI and Co-PI each have over seventeen years of experience in the analysis of the organic species listed above, and are well qualified to advance this field of discovery. These chemical compounds have been designated as persistent bioaccumulative toxics (PBTs), and are believed to possess toxicological properties that are of significant concern to humans and other animal species. Many of these PBTs are hypothesized to be endocrine system disrupting compounds, whose hormonemimicking effects can be manifested at alarmingly low concentrations. Other PBTs are likely present in the environment, but have yet to be identified. Accordingly, developing and perfecting modern analytical techniques to detect, identify, and measure the concentrations of these target compounds at such demanding levels in media such as air and fish tissue is of great importance.The broader impacts of this project will serve to promote fundamental research and discovery, cross-campus collaborations, improvement of laboratory technology, education of university students, and training of aspiring scientists. Undergraduate and master's level research students will gain valuable field, laboratory, analytical, and interpretive experience while working under the supervision of the PI and Co-PI, leading to post-graduate positions in industry, governmental laboratories, and graduate school. These students will be exposed to state-of-the-art analytical techniques required for trace analytical procedures, and they will take the skills and lessons learned from these experiences with them as they advance in their careers. Students will prepare and present results at scientific conferences. Improved laboratory facilities for the PI and Co-PI will attract many prospective students for the future years, and allow these laboratories to remain competitive in pursuits for extramural funding.

提案：0722861PI：迈克尔·S·米利根机构：纽约州立大学弗雷多尼亚学院标题：MRI：采购气相色谱仪器，用于分析新的和新兴的令人关注的化学品和遗留污染物的研究和高级培训这项工作增强了两个主要本科机构的跨校园合作、纽约州立大学 (SUNY) 弗里多尼亚分校和纽约州立大学奥斯威戈分校。纽约州立大学弗雷多尼亚分校的首席研究员（Michael S. Milligan，化学与生物化学系）和纽约州立大学奥斯威戈分校的联合首席研究员（James J. Pagano，化学与环境研究中心）在许多资助和非资助项目中成功合作。 -过去十年资助的研究项目导致许多学生共同撰写出版物和会议摘要。 PI 和 Co-PI 均负责监督致力于样品提取、净化和有机污染物分析的现代分析实验室。通过收购三台气相色谱仪：一台具有更新和现代化的质量选择性检测（包括电子轰击、正离子化学电离和负离子化学电离源）和两台具有电子捕获检测能力，PI和Co-PI将进一步增强他们在分析新出现的令人关注的化合物、内分泌系统干扰化合物（例如氯化二恶英/呋喃 (PCDD/F) 和共面多氯联苯 (PCB)）以及遗留污染物方面拥有专业知识例如大气样本、五大湖鱼类和其他环境介质中发现的多氯联苯、多溴二苯醚 (PBDE) 和有机氯农药。该项目的智力价值涉及用于有机污染物检测和定量的痕量分析技术的开发、进步和完善。这些类型的分析挑战通常需要亚皮克和十亿分之一 (ppb) 的检测限，并且需要复杂的仪器才能成功。 PI 和 Co-PI 均在上述有机物种分析方面拥有超过 17 年的经验，并且完全有资格推进这一发现领域。这些化合物被指定为持久性生物累积性毒物（PBT），并且被认为具有引起人类和其他动物物种高度关注的毒理学特性。许多 PBT 被认为是干扰内分泌系统的化合物，其激素模拟作用可以在极低的浓度下显现出来。其他 PBT 可能存在于环境中，但尚未确定。因此，开发和完善现代分析技术来检测、识别和测量空气和鱼类组织等介质中这些目标化合物的浓度，具有非常重要的意义。该项目的更广泛影响将有助于促进基础研究和发现、跨校园合作、实验室技术的改进、大学生教育以及有抱负的科学家的培训。本科生和硕士水平的研究生将在 PI 和 Co-PI 的监督下工作，获得宝贵的现场、实验室、分析和解释经验，从而获得工业界、政府实验室和研究生院的研究生职位。这些学生将接触到痕量分析程序所需的最先进的分析技术，并且他们将从这些经验中学到的技能和经验教训伴随着他们的职业发展。学生将在科学会议上准备并展示结果。改进的 PI 和 Co-PI 实验室设施将在未来吸引许多潜在的学生，并使这些实验室在追求校外资金方面保持竞争力。