STTR Phase I: Monolithic Multiwavelength Blue-to-IR LED for Biomedical Diagnostics

STTR 第一阶段：用于生物医学诊断的单片多波长蓝光至红外 LED

• 批准号: 0712295
• 负责人: Steven LeBoeuf
• 金额: --
• 依托单位: Valencell Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0712295&HistoricalAwards=false
• 关键词: STTR; Phase; Monolithic; Multiwavelength; Blue

This Small Business Technology Transfer (STTR) Phase I project will demonstrate the feasibility of a novel multi-wavelength light-emitting diode (LED) for transdermal health monitoring of various blood metabolites simultaneously in real time. With independent control of up to 12 spectrally narrow wavelengths, ranging from deep-UV to mid-IR, from a single 1 mm2 LED die, the company's compact multi-wavelength LED will revolutionize traditional pulse oximetry with unprecedented functionality at a significantly lower cost. In contrast with traditional dual-wavelength pulse oximetry, which primarily measures the ratio of oxygenated to deoxygenated blood, the proposed multi-wavelength LED will enable the real-time analysis several additional metabolites critical to health monitoring via the same noninvasive paradigm. Furthermore, combining 12 LEDs into one self-aligned device precludes the need for expensive packaging and complex optical alignment.The medical impact of dual-wavelength pulse oximetry, in both saving lives and reducing healthcare costs, has encouraged the development of broader platforms using additional optical wavelengths. Incorporating 3 or more independently controlled wavelengths has been shown to enable the real-time monitoring of multiple health factors while further reducing readout errors - thus saving more lives. Beyond blood oxygen monitoring, a real-time noninvasive assessment of renal and hepatic health can be realized by integrating several wavelengths in the same clinically accepted pulse oximetry paradigm. The proposed multi-wavelength single-die approach surmounts these limitations by providing independent control of several wavelengths from a single, self-aligned, compact LED. Integrating these advanced, cost-effective optical sources into traditional pulse oximetry opens up new markets in noninvasive metabolic monitoring for paramedics, physical therapists, drug discovery, and home healthcare. As a spectroscopic source, other applications include air-quality/pollution monitoring and agricultural/industrial controls.

这个小型企业技术转移（STTR）I期项目将证明新型多波长发光二极管（LED）的可行性，用于实时同时对各种血液代谢产物的透皮健康监测。从单个1 mm2 LED模具中，从深乌瓦到中期的多达12个频谱狭窄的波长独立控制，该公司的紧凑型多波长LED将革新传统的脉搏血氧饱和度，并且以前所未有的成本较低。与传统的双波长血氧饱和度法相反，该法主要测量了氧化与脱氧血液的比率，拟议的多波长LED将使实时分析通过相同的非侵入性范式进行实时分析，对健康监测至关重要。此外，将12个LED组合成一个自我对准的设备，排除了对昂贵的包装和复杂的光学对齐的需求。在挽救生命和降低医疗保健成本中，双波长脉搏血氧仪的医学影响都鼓励了使用其他光学波长开发更广泛的平台。已显示合并3个或更多独立控制的波长可以实时监测多个健康因素，同时进一步减少读数错误，从而挽救更多的生命。除了血氧监测外，还可以通过在同一临床接受的脉搏血氧仪范式中整合几个波长来实现对肾脏和肝健康的实时无创评估。提出的多波长单DIE方法通过从单个，自我对准的，紧凑的LED提供了几个波长，从而克服了这些局限性。将这些先进的，具有成本效益的光源整合到传统的脉搏血氧仪中，为医护人员，物理治疗师，药物发现和家庭医疗保健的非侵入性代谢监测打开了新市场。作为光谱来源，其他应用包括空气质量/污染监测和农业/工业控制。