Collaborative Research: Chemotaxis in Porous Media--Experimental Observations and Upscaling for Development of a Descriptive Theory

合作研究:多孔介质中的趋化性——实验观察和描述性理论发展的升级

基本信息

  • 批准号:
    0711377
  • 负责人:
  • 金额:
    $ 24.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-15 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

Chemotaxis is the ability of bacteria to sense chemical concentration gradients in their local surroundings and swim toward higher concentrations of chemicals, which they perceive to be beneficial to their survival. In this work, we propose to examine how the pore-scale process of chemotaxis influences the Darcy-scale observation of bacterial transport in porous media. In the subsurface, bioremediation is often hindered by the inability to achieve good mixing between injected substances and the resident contaminants. In such situations, chemotaxis might be exploited to enhance the mixing of bacterial populations within contaminated zones. This would be a multiscale phenomenon in which bacteria migrate in response to pore-scale variations in pollutant concentration that results in greater mixing at the field-scale. There are two closely related open questions for this scheme: (1) how does one relate the pore-scale description of chemotaxis to the effective dispersion tensor that is used to predict bacterial spreading in Darcy-scale applications, and (2) can one also predict the spatial variance of the bacterial concentration to predict the microscale mixing that has occurred within the porous medium. Objective and Approach: The overall goal of this project is to quantify the impact of pore-scale chemotaxis on bacterial transport at the Darcy-scale. We will accomplish this through a combination of theory development and laboratory experimentation in the following steps. 1. Derive a Darcy-scale transport equation for bacteria that accounts for chemotactic responses to local chemical gradients via volume averaging. This will be used to predict (i) the effective dispersion tensor, and (ii) the Darcy-scale spatial variance of the concentration of bacteria.2. Compare theory and experiment for several simplified test cases in which the velocity field and chemical gradients are well-defined. Represent these results as engineering correlations that relate dispersion to dimensionless groups such as the Peclet number and chemotactic driving force.3. Test these correlations experimentally for more complex porous media systems by using microfluidic devices, which allow for direct visualization of fluid flow patterns and bacterial distributions at the pore- and Darcy-scales. Intellectual Merit: To understand the impact of chemotaxis on the biological degradation of chemical contaminants in groundwater systems requires a quantitative analysis that relates the chemotactic response to local chemical gradients over length scales of millimeters to bacterial dispersion over length scales of meters. In our approach we build on current work of hydrologists to model transport of chemical contaminants in groundwater and extend it to motile colloids that are transported due to chemical gradients in addition to hydraulic gradients. The potential for exploiting chemical gradients as a driving force to control the migration of bacterial populations is intellectually appealing. State-of-the-art approaches both in mathematical modeling (upscaling by volume-averaging) and experimental design (microfluidic devices) will be employed in the project.Broader Impact: A new partnership between researchers at the University of Virginia and Oregon State University brings together expertise in the design of experimental systems to quantify bacterial migration and mathematical modeling to relate pore-scale phenomena to field-scale observations. We will encourage students to broaden their experiences through international student exchange and collaboration. Investigators with a proven commitment to recruiting underrepresented groups in engineering will broadly educate one graduate student and one post-doctoral associate in an interdisciplinary context to meet critical needs for environmental engineers in our national workforce. Outreach to local high schools will provide hands-on laboratory experience in genetic engineering for Honors Biology students and their teachers to engage the next generation in the wonder of science. Results from this study will yield engineering correlations to better inform decision-makers about the feasibility of monitored natural attenuation as a treatment option at polluted sites where biological degradation has been documented.
趋化性是细菌感知局部环境中的化学浓度梯度并游向它们认为对其生存有利的更高浓度化学物质的能力。 在这项工作中,我们建议研究孔隙尺度的趋化过程如何影响多孔介质中细菌传输的达西尺度观察。 在地下,生物修复常常因无法实现注入物质与驻留污染物之间的良好混合而受到阻碍。 在这种情况下,可以利用趋化性来增强污染区域内细菌种群的混合。 这将是一种多尺度现象,其中细菌响应污染物浓度的孔隙尺度变化而迁移,从而导致现场尺度上更大的混合。 该方案有两个密切相关的开放问题:(1)如何将趋化性的孔隙尺度描述与用于预测达西尺度应用中细菌扩散的有效分散张量联系起来,以及(2)也可以预测细菌浓度的空间方差,以预测多孔介质内发生的微尺度混合。目标和方法:该项目的总体目标是量化孔尺度趋化性对达西尺度细菌运输的影响。 我们将通过以下步骤结合理论发展和实验室实验来实现这一目标。 1. 推导细菌的达西尺度输运方程,通过体积平均来解释对局部化学梯度的趋化反应。 这将用于预测 (i) 有效分散张量,以及 (ii) 细菌浓度的达西尺度空间方差。2.比较几个简化测试案例的理论和实验,其中速度场和化学梯度被明确定义。 将这些结果表示为工程相关性,将色散与无量纲群(例如佩克莱特数和趋化驱动力)联系起来。3.使用微流体装置对更复杂的多孔介质系统进行实验测试这些相关性,微流体装置可以直接可视化孔隙和达西尺度的流体流动模式和细菌分布。智力价值:为了了解趋化性对地下水系统中化学污染物生物降解的影响,需要进行定量分析,将趋化反应与毫米长度尺度上的局部化学梯度与米长度尺度上的细菌分散联系起来。 在我们的方法中,我们以水文学家当前的工作为基础,对地下水中化学污染物的传输进行建模,并将其扩展到由于化学梯度和水力梯度而传输的运动胶体。 利用化学梯度作为控制细菌种群迁移的驱动力的潜力在智力上很有吸引力。 该项目将采用数学建模(通过体积平均进行升级)和实验设计(微流体装置)方面最先进的方法。更广泛的影响:弗吉尼亚大学和俄勒冈州立大学研究人员之间的新合作伙伴关系汇集了实验系统设计方面的专业知识,以量化细菌迁移和数学建模,以将孔隙尺度现象与现场尺度观测联系起来。 我们将鼓励学生通过国际学生交流与合作来拓宽他们的经验。 致力于招募工程领域代表性不足群体的研究人员将在跨学科背景下广泛教育一名研究生和一名博士后助理,以满足我们国家劳动力中环境工程师的关键需求。 推广到当地高中将为荣誉生物学学生和他们的老师提供基因工程方面的实践实验室经验,让下一代体验科学的奇迹。 这项研究的结果将产生工程相关性,以便更好地告知决策者在已记录生物降解的污染地点将监测的自然衰减作为一种处理方案的可行性。

项目成果

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Roseanne Ford其他文献

Roseanne Ford的其他文献

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{{ truncateString('Roseanne Ford', 18)}}的其他基金

Collaborative Research: EAGER: Exploring beyond visualization: Data sonification of bacterial chemotaxis patterns
合作研究:EAGER:超越可视化的探索:细菌趋化模式的数据超声处理
  • 批准号:
    1950369
  • 财政年份:
    2020
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Collaborative Research: A Multiscale Analysis of Chemotactic Bacteria Transport in Heterogeneous Porous Media
合作研究:异质多孔介质中趋化细菌传输的多尺度分析
  • 批准号:
    1141400
  • 财政年份:
    2012
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Field-scale study to evaluate the role of bacterial chemotaxis in natural attenuation of groundwater contaminants
评估细菌趋化性在地下水污染物自然衰减中的作用的现场研究
  • 批准号:
    0408454
  • 财政年份:
    2004
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
BIOCOMPLEXITY - INCUBATION ACTIVITY: Quantitative description of the response of a complex system to disturbance: subsurface microbial communities and chemical contaminants
生物复杂性 - 孵化活动:复杂系统对扰动响应的定量描述:地下微生物群落和化学污染物
  • 批准号:
    0083839
  • 财政年份:
    2000
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
LExEN: Survival Strategies of the Hyperthermophilic Bacterium Thermatoga maritima Under Extreme Temperatures
LExEN:极端温度下超嗜热细菌 Thermatoga maritima 的生存策略
  • 批准号:
    9809388
  • 财政年份:
    1998
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Quantification of Bacterial Transport Processes in Subsurface Environments
地下环境中细菌传输过程的量化
  • 批准号:
    9524544
  • 财政年份:
    1996
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Continuing Grant
Quantitative Characterization of Bacterial Chemotaxis in Natural Microbial Processes
自然微生物过程中细菌趋化性的定量表征
  • 批准号:
    9109948
  • 财政年份:
    1991
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Microbial Migration: Implications for Bioremediation Technologies
微生物迁移:对生物修复技术的影响
  • 批准号:
    9009725
  • 财政年份:
    1990
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant

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相似海外基金

Collaborative Research: EAGER: Exploring beyond visualization: Data sonification of bacterial chemotaxis patterns
合作研究:EAGER:超越可视化的探索:细菌趋化模式的数据超声处理
  • 批准号:
    1950369
  • 财政年份:
    2020
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Collaborative Research: EAGER: Exploring beyond visualization: Data sonification of bacterial chemotaxis patterns
合作研究:EAGER:超越可视化的探索:细菌趋化模式的数据超声处理
  • 批准号:
    1951027
  • 财政年份:
    2020
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Collaborative Research: Viral induced chemotaxis mediating cross-trophic microbial interactions and carbon flux
合作研究:病毒诱导的趋化性介导跨营养微生物相互作用和碳通量
  • 批准号:
    1829905
  • 财政年份:
    2018
  • 资助金额:
    $ 24.01万
  • 项目类别:
    Standard Grant
Collaborative Research: Viral induced chemotaxis mediating cross-trophic microbial interactions and carbon flux
合作研究:病毒诱导的趋化性介导跨营养微生物相互作用和碳通量
  • 批准号:
    1829827
  • 财政年份:
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The role and mechanism of TNFAIP8 in intestinal inflammation and wound healing
TNFAIP8在肠道炎症和伤口愈合中的作用及机制
  • 批准号:
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