Transient Surface Temperature Response as Diagnostic Tool in Medicine and Engineering Applications

瞬态表面温度响应作为医学和工程应用中的诊断工具

• 批准号: 0651981
• 负责人: Cila Herman
• 金额: --
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0651981&HistoricalAwards=false
• 关键词: Transient; Surface; Temperature; Response; Diagnostic

0651981 TRANSIENT SURFACE TEMPERATURE RESPONSE AS DIAGNOSTIC TOOL INMEDICINE AND ENGINEERING APPLICATIONSThe surface temperatures of layered systems, such as skin, vary under external heating or cooling depending on the properties and arrangement of subsurface structures and the imposed thermal boundary conditions. Biological systems typically have spatially distributed internal heat sources linked to metabolic activity and blood flow. The goal of the project is to investigate the transient surface temperature response to cooling or heating in order to identify subsurface structures and processes. Prior studies by the investigators suggest that, in cases of practical significance (skin cancers such as melanoma) a correlation between the transient surface temperature signature and the size, shape and location of the subsurface structures (cancerous lesions) can be established. In order to relate transient surface temperature signature to subsurface structures, accurate mathematical models are being developed and verified experimentally. The objective is to develop relatively inexpensive, non-invasive, rapid measurement and diagnostic tools, based on transient infrared surface temperature measurements and interpreted using numerical modeling, for the identification of subsurface structures of practical interest (for example, the diagnosis of melanoma, detection of failure in composite structures, etc.). The research will lead to the development of better models of healthy and cancerous tissues and their response to thermal excitation. Cancer is the second leading cause of death in the United States. Currently, melanoma is the fastest growing malignancy in the US with the lifetime risk being 1 in 68 and the key to survival remains early detection and surgical excision. To date, no effective screening tools have been developed to enhance the early diagnosis of this disease and the criteria for diagnosis remain subjective. The existence of a relatively simple, non-invasive and inexpensive diagnostic tool, such as the one to be investigated in this project, for conditions that are life threatening, including malignant melanoma, would have a wide-ranging impact on people affected by these conditions. The proposed research holds the promise of allowing the identification of cancerous (as opposed to benign growth) without biopsy.

0651981 瞬态表面温度响应作为医学和工程应用中的诊断工具层状系统（例如皮肤）的表面温度在外部加热或冷却下会发生变化，具体取决于地下结构的特性和排列以及施加的热边界条件。生物系统通常具有与代谢活动和血流相关的空间分布的内部热源。该项目的目标是研究瞬态表面温度对冷却或加热的响应，以识别地下结构和过程。研究人员之前的研究表明，在具有实际意义的情况下（皮肤癌，如黑色素瘤），可以建立瞬态表面温度特征与地下结构（癌性病变）的大小、形状和位置之间的相关性。为了将瞬态表面温度特征与地下结构联系起来，正在开发精确的数学模型并通过实验进行验证。目标是开发相对便宜、非侵入性、快速的测量和诊断工具，基于瞬态红外表面温度测量并使用数值模型进行解释，用于识别实际感兴趣的地下结构（例如，黑色素瘤的诊断、检测复合材料结构的失效等）。该研究将有助于开发更好的健康和癌组织模型及其对热激发的反应。癌症是美国第二大死因。目前，黑色素瘤是美国增长最快的恶性肿瘤，终生患病风险为六十八分之一，生存的关键仍然是早期发现和手术切除。迄今为止，尚未开发出有效的筛查工具来加强这种疾病的早期诊断，并且诊断标准仍然是主观的。存在一种相对简单、非侵入性且廉价的诊断工具，例如本项目中要研究的工具，用于治疗危及生命的疾病，包括恶性黑色素瘤，将对受这些疾病影响的人们产生广泛的影响。拟议的研究有望在不进行活检的情况下识别癌变（而不是良性生长）。