CRIF: MU Purchase of an LC/Ion Trap Mass Spectrometer

CRIF：MU 购买 LC/离子阱质谱仪

基本信息

批准号：
0639208
负责人：
Robert Bateman
金额：
$ 28.01万
依托单位：
University of Southern Mississippi
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-15 至 2010-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0639208&HistoricalAwards=false
关键词：
CRIF MU Purchase LC Ion

项目摘要

The Chemistry Department at Southern Mississippi University will acquire a liquid chromatography (LC) ion trap mass spectrometer with this award from the Chemistry Research Instrumentation and Facilities: Multi User (CRIF:MU) program. The instrument will be employed in a wide variety of research projects supporting structural, reaction, and analytical studies of: 1) gas phase peptide and protein digestion; 2) paramagnetic transition metal complexes used as asymmetric catalysts in epoxidation and hydroxylation reactions; 3) enzymology of bioctive peptide maturation; 4) the carboxysome assembly pathway and the arrangement and interactions between shell proteins; 5) nucleoid proteins and potential posttranslational modifications that might affect their interaction with ctDNA; and 6) RNA-catalysts.Mass spectrometry analysis is used in chemical and biochemical research to identify molecules and their structures by measuring the mass of the compounds under study. Liquid chromatography precedes the mass spectral analysis by separating and purifying a mixture of compounds into its simpler components. Training in mass spectrometry analysis is integral to the professional development of chemistry, biochemistry and materials science students. This instrument will be used in undergraduate laboratory course instruction and in the research projects of undergraduates and graduate students.

南密西西比大学化学系将获得化学研究仪器和设施：多用户 (CRIF:MU) 计划授予的液相色谱 (LC) 离子阱质谱仪。该仪器将用于支持结构、反应和分析研究的各种研究项目：1) 气相肽和蛋白质消化； 2）顺磁性过渡金属配合物在环氧化和羟基化反应中用作不对称催化剂； 3)生物活性肽成熟的酶学； 4）羧基体组装途径以及壳蛋白之间的排列和相互作用； 5) 类核蛋白和可能影响其与 ctDNA 相互作用的潜在翻译后修饰； 6) RNA 催化剂。质谱分析用于化学和生化研究，通过测量所研究化合物的质量来识别分子及其结构。液相色谱法先于质谱分析，将化合物的混合物分离并纯化成更简单的成分。质谱分析培训是化学、生物化学和材料科学学生专业发展不可或缺的一部分。该仪器将用于本科生实验课程教学以及本科生和研究生的研究项目。