Linking Evolution to Genomics Using Phenotype Ontologies

使用表型本体将进化与基因组学联系起来

• 批准号: 0641025
• 负责人: Paula Mabee
• 金额: --
• 依托单位: University of South Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2011-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0641025&HistoricalAwards=false
• 关键词: Linking; Evolution; Genomics; Using; Phenotype

The University of South Dakota Main Campus is awarded a grant to develop tools to integrate evolutionary and model organism phenotype data using ontologies in order to address questions about the genetic and developmental regulation of evolutionary morphological transitions. The project will develop and apply ontologies for taxa and phenotypes in a large clade of fishes (the Ostariophysi) and to develop a suite of database and web-interface tools that will enable researchers to investigate relationships between evolutionary phenotypes and those seen in genetically characterized developmental mutants of zebrafish (a species within Ostariophysi). Combining the wealth of genomic data on the numerous phenotypic mutants for zebrafish, with the span of corresponding anatomical diversity in ostariophysan species will allow researchers to discover previously unrealized connections between evolutionary change, genes, and the developmental processes in which these genes play a role. The team will demonstrate the feasibility of the approach by implementing a select number of use-case queries as a proof-of-concept. The queries will be implemented via a web-based user interface for searching and analyzing the data content. The research will be carried out in collaboration with the National Evolutionary Synthesis Center at the University of North Carolina.

南达科他大学主要校园获得了一项赠款，以开发工具，以使用本体论来整合进化和模型的有机物表型数据，以解决有关进化形态过渡的遗传和发展调节的问题。该项目将在大量鱼类（Ostariophysi）中开发和应用本体分类型和表型，并开发一套数据库和Web-Interface工具，使研究人员能够研究进化表型与Zebrafish（一种物种属于Ostariyphysophysophysophysophysiphysophysiphysiphysiphys）的进化表型之间的关系。结合斑马鱼的众多表型突变体的基因组数据，以及在Ostariophysan物种中相应的解剖学多样性的跨度将使研究人员能够发现以前未实现的连接，基因，基因和发育过程中这些基因起着这些作用。该团队将通过实施选定数量的用例查询作为概念验证来证明该方法的可行性。这些查询将通过基于Web的用户界面实现，以搜索和分析数据内容。该研究将与北卡罗来纳大学国家进化合成中心合作进行。