SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy

SGER：通过高速共焦显微镜观察微通道中的 3D 悬浮液传输

• 批准号: 0630191
• 负责人: James Gilchrist
• 金额: $ 8万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0630191&HistoricalAwards=false
• 关键词: SGER; Observation; 3D; Suspension; Transport

ABSTRACTProposal Number: CTS-0630191Principal Investigator: Gilchrist, James F.Affiliation: Lehigh UniversityProposal Title: SGER: Observation of 3D Suspension Transport in Microchannels via High-Speed Confocal Microscopy Intellectual Merit:The exploratory research program will investigate behavior of suspensions in simple and 3Dflows in microchannels. Particle-particle, particle-fluid and particle-field interactions generating particle migration can result in particle self-organization into non-uniform particle distributions. In competition with these processes, chaotic advection, generated by spatial or temporal perturbations to the flow, and diffusion typically result in enhanced dispersion. This study is the first direct investigation of the interplay between flow-induced dispersion and self-organization in microscale systems. Initial exploration of the competition between order and disorder in these systems will be realized via high-speed laser scanning confocal microscopy (CLSM, VisiTech International). These measurements will eventually be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows.Broader Impacts:Particulate flows in microfluidic geometries are important for cell separations and otheranalytical operations that will likely be the focus of lab-on-a-chip systems of the future. This work will provide both graduate and undergraduate educational opportunities in an area at the convergence of several technologically-critical research areas, including microfluidics and suspension structure. At the graduate level, information disseminated from this research regarding 3D mixing and colloidal flows in microchannels will be incorporated into graduate level Transport Phenomena. For undergraduates, semester/summer research opportunities will provide hands-on experience with microfluidics, suspensions, and high speed CLSM. Information related to this project will be presented at national conferences as well as to local interest groups such as the Lehigh Nanotechnology Network, a consortium of regional companies interested in materials and transport processes at the micro and nanoscale.

摘要提案编号：CTS-0630191主要研究员：Gilchrist, James F.隶属关系：里哈伊大学提案标题：SGER：通过高速共焦显微镜观察微通道中的 3D 悬浮液传输智力优点：该探索性研究计划将研究简单流动和 3D 流动中悬浮液的行为在微通道中。产生粒子迁移的粒子-粒子、粒子-流体和粒子-场相互作用可以导致粒子自组织成不均匀的粒子分布。在与这些过程的竞争中，由对流动的空间或时间扰动产生的混沌平流和扩散通常会导致扩散增强。这项研究是首次直接研究微尺度系统中流动引起的色散与自组织之间的相互作用。对这些系统中有序与无序之间竞争的初步探索将通过高速激光扫描共焦显微镜（CLSM，VisiTech International）实现。这些测量最终将用于挑战目前的模型，这些模型估计 3D 混沌流中颗粒迁移产生的浓度分布。更广泛的影响：微流体几何形状中的颗粒流对于细胞分离和其他分析操作非常重要，这些操作可能会成为实验室的重点未来的芯片系统。这项工作将为研究生和本科生提供几个关键技术研究领域（包括微流体和悬浮结构）融合领域的教育机会。在研究生阶段，这项研究传播的有关微通道中 3D 混合和胶体流动的信息将被纳入研究生阶段的传输现象中。对于本科生来说，学期/夏季研究机会将提供微流体、悬浮液和高速 CLSM 的实践经验。与该项目相关的信息将在国家会议以及当地利益团体（如 Lehigh 纳米技术网络）上公布，该网络是一个由对微米和纳米尺度的材料和运输过程感兴趣的地区公司组成的联盟。