MRI: Aquisition of Apparatus to Support Multi-User Basic Research and Instruction in the Neurosciences

MRI：购买支持神经科学多用户基础研究和教学的设备

• 批准号: 0619544
• 负责人: Craig Kinsley
• 金额: $ 27.4万
• 依托单位: University of Richmond
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0619544&HistoricalAwards=false
• 关键词: MRI; Aquisition; Apparatus; Support; Multi

This award provides support to The University of Richmond (UR) for a suite of neuroscience and animal behavioral-recording equipment, which includes a fluorescence microscope with motorized stage and image analysis (IA) capabilities; motorized cryostat; histological processing system; tissue-sectioning Vibratome; neuron tracing software; automated behavioral analysis system with touch screen; acoustic startle boxes; and activity monitors. This complementary and high-throughput equipment will allow UR and affiliated students and faculty to make further advances in understanding the development of the brain. Several different combinations of investigators will use the requested equipment: research faculty and postdoctoral fellows at UR in Neuroscience, Psychology and Biology; faculty, graduate and undergraduate students from UR and affiliated universities and colleges (Randolph-Macon College, in Ashland, VA; Virginia Union University, a Historically Black College in Richmond, VA; Dickinson College, Carlisle, PA); and students and faculty from international institutions.These faculty and students will design behavioral experiments that can be analyzed by the latest objective automated behavioral recording devices, including basic and complex social interactions. The cryostat and Vibratome and automated immunohistological apparatus will allow faster, more efficient, and more reliable processing of brain tissue. Automated IA and neuronal identification and 3-dimensional drawing features, as well as new double- and triple-labeling immunofluorescent techniques will provide precise neuronal localization of important neurochemicals. In sum, this equipment will allow the investigators to conduct many detailed, comprehensive, and complementary behavioral, and multiple antigen-labeling studies of maternal and paternal brains - studies that heretofore were difficult to perform well, if at all. The addition of this apparatus will significantly increase the numbers of students -- broadly defined, on and off-campus, international, etc. -- that can be exposed to, and gain experience in, basic research and instruction in the neurosciences. In the process, these investigators can answer valuable questions, train a significant number of future scientists, and share the information with the scientific and lay communities alike, which include local and national media, and metro-Richmond K-12 schools, museums, and hospitals.

该奖项为里士满大学 (UR) 提供一套神经科学和动物行为记录设备的支持，其中包括具有电动载物台和图像分析 (IA) 功能的荧光显微镜；电动低温恒温器；组织学处理系统；组织切片振动切片机；神经元追踪软件；带触摸屏的自动行为分析系统；声学惊吓盒；和活动监视器。 这种互补的高通量设备将使 UR 及其附属学生和教师在理解大脑发育方面取得进一步进展。 几种不同的研究人员组合将使用所需的设备：UR 神经科学、心理学和生物学领域的研究人员和博士后研究员；来自 UR 及其附属大学和学院（弗吉尼亚州阿什兰的伦道夫-梅肯学院；弗吉尼亚联合大学，弗吉尼亚州里士满的一所历史悠久的黑人学院；宾夕法尼亚州卡莱尔的迪金森学院）的教师、研究生和本科生；来自国际机构的学生和教师。这些教师和学生将设计可以通过最新的客观自动行为记录设备进行分析的行为实验，包括基本和复杂的社交互动。 低温恒温器、振动切片机和自动免疫组织学设备将能够更快、更高效、更可靠地处理脑组织。 自动 IA 和神经元识别、3 维绘图​​功能以及新的双标记和三标记免疫荧光技术将提供重要神经化学物质的精确神经元定位。 总之，该设备将允许研究人员对母亲和父亲的大脑进行许多详细、全面和补充的行为和多重抗原标记研究——迄今为止，这些研究很难顺利进行。 该设备的增加将显着增加学生数量（广义上的、校内和校外的、国际学生等）的数量，这些学生可以接触神经科学的基础研究和教学并获得经验。 在此过程中，这些调查人员可以回答有价值的问题，培训大量未来的科学家，并与科学界和非专业社区分享信息，其中包括当地和国家媒体以及里士满都会区的 K-12 学校、博物馆和机构。医院。