Cucurbit[10]uril

葫芦[10]脲

• 批准号: 0615049
• 负责人: Lyle Isaacs
• 金额: $ 56.3万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0615049&HistoricalAwards=false
• 关键词: Cucurbit; 10; uril

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Lyle D. Isaacs of the Chemistry Department at the University of Maryland, College Park, MD. This research will investigate the use of cucurbit[10]uril (CB[10]), the largest cucurbit[n]uril known, as a molecular container in aqueous solution. In particular, the use of CB[10] as molecular chaperone to control the folding of melamine oligomers into well-defined conformations will be explored. In addition, complexes between CB[10] and cationic (metallo)porphyrins will be prepared and their use in forming termolecular complexes with suitable molecular guests will be investigated. The CB[10]-porphyrin complexes will also be applied as catalysts for oxidation reactions in water. This project will also investigate the possibility of allosteric control of the macromolecular conformation of cationic calixarenes inside CB[10] by the introduction of small molecules. These experiments will evaluate the potential for cucurbiturils to function as real-world molecular containers for applications such as drug delivery. This project will foster the training of students at all academic levels, including a number from underrepresented groups, as interdisciplinary scientists.

通过这一新奖项，有机和高分子化学项目支持马里兰大学帕克分校化学系 Lyle D. Isaacs 教授的工作。 本研究将研究已知最大的葫芦[n]脲（CB[10]）作为水溶液中的分子容器的用途。 特别是，将探索使用 CB[10] 作为分子伴侣来控制三聚氰胺低聚物折叠成明确的构象。 此外，还将制备CB[10]和阳离子（金属）卟啉之间的配合物，并研究它们在与合适的分子客体形成三分子配合物中的用途。 CB[10]-卟啉配合物也将用作水中氧化反应的催化剂。 该项目还将研究通过引入小分子对CB[10]内部阳离子杯芳烃大分子构象进行变构控制的可能性。 这些实验将评估葫芦脲作为药物输送等应用的真实分子容器的潜力。该项目将促进对各个学术层次的学生进行跨学科科学家的培训，其中包括一些来自代表性不足群体的学生。