STTR Phase I: Miniature Biosensor Utilizing Nanomaterial Coatings

STTR 第一阶段：利用纳米材料涂层的微型生物传感器

• 批准号: 0611093
• 负责人: Michael Miller
• 金额: $ 9.98万
• 依托单位: PRIME RESEARCH LC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0611093&HistoricalAwards=false
• 关键词: STTR; Phase; Miniature; Biosensor; Utilizing

This Small Business Technology Transfer (STTR) program proposes combining photonic sensing, nanotechnology and biotechnology to demonstrate a new type of biosensor for laboratory use and rapid response to biological threats. The proposed device will be constructed from a new type of chemical-biological sensor which uses fiber optic grating sensor technology enhanced with unique new nanomaterial coatings. The combination of the new sensing method with the nanomaterial properties will result in a low-cost, rapid, highly sensitive and miniature device capable of battery operation and integration into a deployable unit. Detection has been demonstrated both for fluid-borne and air-borne targets, and the technique will detect bacteria, nerve agents, proteins and explosives. Expected detection limits for the final device range from 100 to 1000 times better than is currently possible using existing laboratory systems. Development of such a biosensor will require a concerted multidisciplinary effort in optical physics, biochemistry, and polymer and interfacial chemistry. If successful the proposed project will advance scientific knowledge in the following areas: (1) Advance the understanding of photonic sensing through the study of electromagnetic/optical field interactions in the photonic waveguide structures and in the overlying nanomaterial films, (2) Advance the development of nanomaterial applications through study of the covalent binding mechanisms between the affinity ligands and the ionic self-assembled multilayers (ISAM) film polymers, resulting in a general procedure for incorporating multiple classes of targets, (3) Advance the development of combinatorial evaluation techniques utilizing automated reasoners to reduce the requirement for high specificity sensing vectors, ultimately leading to intelligent sensing and reduced false alarm indications, and (4) Provide advanced educational opportunities through support of graduate and undergraduate students at Virginia Tech, specifically in the condensed matter and biotechnology areas.

这个小型企业技术转移（STTR）计划建议将光子传感，纳米技术和生物技术结合起来，以展示一种用于实验室使用的新型生物传感器，以及对生物威胁的快速响应。提出的设备将由一种新型的化学生物传感器构建，该化学生物传感器使用光纤光栅传感器技术通过独特​​的新纳米材料涂料增强。新的传感方法与纳米材料特性的组合将导致低成本，快速，高度敏感和微型设备能够电池操作并集成到可部署的单元中。已经证明了用于流体传播和空气靶标的检测，该技术将检测细菌，神经剂，蛋白质和爆炸物。最终设备的预期检测限量是使用现有实验室系统的目前可能的100至1000倍。这种生物传感器的开发将需要在光学物理，生物化学以及聚合物和界面化学方面进行一致的多学科工作。如果成功的项目将在以下领域中提高科学知识：（1）通过研究光电/光场在光子波导结构和上上覆的纳米材料膜中的电磁/光场相互作用来提高对光子感测的理解，（2）通过研究纳米材料应用的发展，通过研究纳米材料的发展，从而在共同的结合机构之间进行研究（和iShimismsismissiral ins of ligigional and ligi ligi ligi and limandion and）（胶片聚合物，导致了一类用于合并多种目标的一般程序，（3）推进了使用自动推理的组合评估技术的发展，以减少对高特异性感应媒介的需求，最终导致智能感应和降低虚假警报指示，（4）通过对弗吉尼亚州的研究生和培训专业的学生进行研究，以提供教育的领域。