Processing and Characterization of Functionally Graded Coatings for Bio-Medical Implants

生物医学植入物功能梯度涂层的加工和表征

• 批准号: 0600596
• 负责人: Afsaneh Rabiei
• 金额: $ 22万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0600596&HistoricalAwards=false
• 关键词: Processing; Characterization; Functionally; Graded; Coatings

The aim of this research program is to develop a functionally graded Hydroxyapatite (FGHA) coating for orthopedic and dental implants with a tailored release rate of an antimicrobial component. In this case, the antimicrobial element will have a higher release rate together with the mostly amorphous layer at the surface of the coating immediately after implantation, and its release rate will gradually decreases with increasing crystallinity of the coating. Furthermore, the proposal aims to increase the service-life of an orthopedic/ dental implant by creating coatings that forms a strong, long lasting bond not only with the juxtaposed bone, but also with the metal substrate. All this will translate into the patient receiving an orthopedic or dental implant, with a superior bioactive coating with an integrated antimicrobial component. As a result, the patient could return to a normal lifestyle sooner with the reduced antibiotics intake along with less risk of infection and its subsequent complications.The proposed study investigates a new coating material with tailored dissolution rate that can match with bone growth together with gradually released antimicrobial components that can have a great impact on the development of the next generation of orthopedic and dental implants with improved durability, along with better biological responses. The education plan involves four complementary initiatives including: interdisciplinary research based on collaboration between three different departments at two university in US and the Japan National Institute of Materials Science, new graduate course development on Advanced Materials including Biomaterials, team work between undergraduate and graduate students and a special attempt to hiring female, underrepresented and disabled students

该研究计划的目的是开发一种用于骨科和牙科植入物的功能分级羟基磷灰石 (FGHA) 涂层，具有定制的抗菌成分释放率。在这种情况下，抗菌元件在植入后立即与涂层表面的大部分非晶层一起具有较高的释放速率，并且其释放速率将随着涂层结晶度的增加而逐渐降低。此外，该提案旨在通过创建涂层来延长骨科/牙科植入物的使用寿命，该涂层不仅与并置的骨骼形成牢固、持久的结合，而且还与金属基底形成牢固、持久的结合。所有这些都将转化为接受整形外科或牙科植入物的患者，该植入物具有具有集成抗菌成分的卓越生物活性涂层。因此，患者可以通过减少抗生素摄入量更快地恢复正常生活方式，同时降低感染及其后续并发症的风险。这项研究研究了一种具有定制溶解速率的新型涂层材料，该材料可以与骨骼生长相匹配，并逐渐释放的抗菌成分可以对下一代骨科和牙科植入物的开发产生巨大影响，这些植入物具有更高的耐用性和更好的生物反应。该教育计划涉及四项互补举措，包括：基于美国两所大学和日本国立材料科学研究所三个不同部门之间合作的跨学科研究、包括生物材料在内的先进材料的新研究生课程开发、本科生和研究生之间的团队合作以及雇用女性、代表性不足和残疾学生的特殊尝试