Collaborative Research: Ecological Interactions between Sudden Oak Death and Lyme Disease in California

合作研究：加利福尼亚州橡树猝死与莱姆病之间的生态相互作用

• 批准号: 0525674
• 负责人: Richard Ostfeld
• 金额: --
• 依托单位: Cary Institute of Ecosystem Studies, Inc.
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-10-01 至 2011-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0525674&HistoricalAwards=false
• 关键词: Collaborative; Research; Ecological; Interactions; between; Collaborative; Research; Ecological; Interactions; between

A devastating plant pathogen, Phytophthora ramorum, which causes the disease Sudden Oak Death (SOD), is sweeping through oak woodlands of California. This new disease has the potential to profoundly affect local vertebrate populations. Vertebrate populations (e.g., mice, squirrels, lizards), in turn, strongly influence risk of human exposure to Lyme disease (LD) via their impacts on numbers and infection of tick vectors. This research will integrate field, laboratory, and modeling efforts. First, a combination of field and lab studies will furnish information on individual host species' contributions to LD risk in California. Second, the abundance of specific groups of vertebrates will be compared in sites of high versus low SOD impact. Third, responses by specific hosts to SOD will be used to construct models to predict how SOD will change risk of human exposure to LD. Fourth, specific hypotheses arising from these models will be tested by assessing tick abundance and infection prevalence in areas of high and low SOD impact.Our research embeds the ecology of the most prevalent vector-borne disease of humans in the United States (LD) within the ecology of a devastating infectious disease of plants (SOD), and specifically asks how these two disease systems interact. The outbreak of SOD presents a novel opportunity to determine how a human infectious disease is impacted by an exotic forest pathogen. Such research provides a model for current epidemics of plant pathogens and pests (e.g., beech bark disease, hemlock woolly adelgid, gypsy moth) that in all likelihood will dramatically change the composition of North American forests, with potentially strong consequences for human health.

毁灭性的植物病原体植物菌ramorum造成疾病猝死（SOD），正在加利福尼亚州的橡树林席卷。这种新疾病有可能对局部脊椎动物种群产生深远的影响。脊椎动物种群（例如，小鼠，松鼠，蜥蜴）又通过对tick矢量的数量和感染的影响而强烈影响人类暴露于莱姆病（LD）的风险。这项研究将整合现场，实验室和建模工作。首先，现场研究的结合将提供有关单个寄主物种对加利福尼亚LD风险的贡献的信息。其次，将在高SOD撞击与低SOD撞击部位比较特定脊椎动物的丰度。第三，特定主机对SOD的反应将用于构建模型，以预测SOD将如何改变人类接触LD的风险。第四，这些模型产生的特定假设将通过评估高和低草皮影响领域的壁虱丰度和感染的流行。 SOD的爆发带来了一个新的机会，可以确定人类传染病如何受到异国森林病原体的影响。这样的研究为当前的植物病原体和害虫流行（例如，山毛榉树皮疾病，Hemlock Woolly Adelgid，Gypsy Moth）提供了模型，该模型很有可能会大大改变北美森林的组成，并可能对人类健康产生强大的后果。