ME: Molecular Network Controls of Hepatocyte Metabolism

ME：肝细胞代谢的分子网络控制

• 批准号: 0519563
• 负责人: Charles Roth
• 金额: $ 99.87万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0519563&HistoricalAwards=false
• 关键词: ME; Molecular; Network; Controls; Hepatocyte

Roth0519563The proposed research involves the development of novel approaches to model regulation of metabolic networks, with a particular focus on gene regulation and cellular signaling. This approach combines gene expression data acquisition and a modeling framework, which utilizes experimental data and biological knowledge in unique ways, and which will have significant impact on the field of systems biology. The effect of stress mediators on hepatocyte metabolism has not been studied extensively and quantitatively from the standpoint of re-directing metabolism from inflammation to differentiated function for tissue engineering applications.This project will expand on collaborations already developed among the Principal Investigators (PIs) to include a larger and more diverse team, including experts in liver physiology and development of a bioartificial liver, biochemical reaction modeling, optimization, and data mining. Several graduate students will be supported by this grant. Other students are on fellowships from the Rutgers IGERT program on Integratively Engineered Biointerfaces. All students will be co-advised by 2 PIs and receive cross-disciplinary training. This project will be used as a case study in the PI's Molecular and Cellular Bioengineering course. Because of the integrative and interdisciplinary nature of this project, a significant impact on the educational and research infrastructure at Rutgers is expected.

ROTH0519563提出的研究涉及开发新型方法​​，以模拟代谢网络的调节，特别关注基因调节和细胞信号传导。 这种方法结合了基因表达数据获取和建模框架，该框架以独特的方式利用了实验数据和生物学知识，并将对系统生物学领域产生重大影响。 The effect of stress mediators on hepatocyte metabolism has not been studied extensively and quantitatively from the standpoint of re-directing metabolism from inflammation to differentiated function for tissue engineering applications.This project will expand on collaborations already developed among the Principal Investigators (PIs) to include a larger and more diverse team, including experts in liver physiology and development of a bioartificial liver, biochemical reaction建模，优化和数据挖掘。 该赠款将为几位研究生提供支持。 其他学生正在从Rutgers Igert计划进行集成工程生物界面的奖学金。 所有学生都将通过2个PI共同努力，并接受跨学科培训。该项目将在PI的分子和细胞生物工程课程中用作案例研究。由于该项目的综合性和跨学科性质，预计将对罗格斯的教育和研究基础设施产生重大影响。