Protein Kinase Resource

蛋白激酶资源

• 批准号: 0514112
• 负责人: Michael Gribskov
• 金额: --
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0514112&HistoricalAwards=false
• 关键词: Protein; Kinase; Resource

The majority of biological databases today are broad, but shallow, covering large amounts of material but in a relatively cursory way. These are essential resources as scientists use molecular biological techniques to develop a catalog of the molecules founds in living cell. Now, it is time to move beyond simply cataloguing the molecules of a cell toward the time for understanding the dynamic interactions between molecules within a cell. This level of understanding requires a different kind of database, one that links together sequence, genetics, structure and function to create a deeper resource. The existing Protein Kinase Resource (PKR, http://pkr.sdsc.edu) will be extended to create a resource from which both novices and experts can learn about protein kinases, an important family of enzymes that play roles in processes as diverse as human disease and crop production. From a technical standpoint, the resource will integrate data from a variety of existing resources in ways not previously achieved. The integration at UCSD provides a location for developing detailed and well defined application program interfaces (APIs) that will allow these resources to interoperate. It will deliver both content and technological advances in the field of biological databases. All data, software and specifications will be publicly available. Beyond students involved in the research, workshops will provide instruction in community annotation of kinases using the PKR and ways to adapt the database for other uses. Modules of the database and APIs will enable the utilization of this work by other groups interested in other enzyme families.

当今的大多数生物数据库都是广泛但浅的，涵盖了大量材料，但以相对粗略的方式。 这些是必不可少的资源，因为科学家使用分子生物学技术来开发活细胞中发现的分子的目录。 现在，现在是时候简单地将细胞的分子分类到理解细胞内分子之间的动态相互作用的时候了。 这种理解水平需要一种不同的数据库，该数据库将序列，遗传学，结构和功能链接在一起以创建更深的资源。 现有的蛋白激酶资源（PKR，http://pkr.sdsc.edu）将扩展到创建一种资源，从中，新手和专家都可以从中了解蛋白激酶，蛋白激酶是一个重要的酶家族，在与人类疾病和作物产量一样多样化的过程中起着作用。 从技术角度来看，资源将以以前未实现的方式整合来自各种现有资源的数据。 UCSD的集成提供了一个用于开发详细且定义明确的应用程序界面（API）的位置，该界面将允许这些资源互操作。 它将在生物数据库领域提供内容和技术进步。 所有数据，软件和规格都将公开可用。 除了参与研究的学生之外，研讨会还将使用PKR提供有关激酶社区注释的指导，以及将数据库适应其他用途的方法。 数据库和API的模块将使对其他酶家族感兴趣的其他群体能够利用这项工作。