Segregation in Multicomponent Macromolecular Systems

多组分大分子系统中的分离

• 批准号: 0414446
• 负责人: Monica Olvera
• 金额: $ 30万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414446&HistoricalAwards=false
• 关键词: Segregation; Multicomponent; Macromolecular; Systems

This award supports theoretical research that will analyze the statistics andthermodynamics of self-associating neutral and charged macromolecules in various environments. In particular, we will determine the structure and phase diagram of solutions of macromolecules with site-specific interactions such as heterogeneous polymers with associating end groups and peptide amphiphile molecules. Heterogeneous molecules with associating end groups form micelles and/or clusters. When their concentration increases the clusters expand over the whole system leading to gel-like structures. The physical properties of these gels will be analyzed as a function of the functionality of the associating groups and the excluded volume of the molecules. We will also analyze the effect of charge on the polymer backbone and of the salt in the environment on the thermodynamics of charged chain solutions with strong site-specific attractions. The association of peptide amphiphile molecules into cylindrical micelles will be analyzed as a function of the concentration and charge of the peptide. We will include hydrogen bonding in the self-associating model and compare its effect on the micelle structure to peptides with dipoles perpendicular to the backbones. Mixtures of peptides amphiphiles of opposite charge will also be analyzed as candidates for cylindrical micelles with specific surface structures driven by the segregation of the This award supports theoretical research that will analyze the statistics and peptides.Research goals are to generate new models to guide the synthesis and fabrication of new materials involving heterogeneous macromolecules and multicomponent solutions. These systems are capable of self-organizing in a large number of remarkable structures. Our results will aid the design of various experimental systems including non-aqueous thermoreversible gels with controllable adhesive properties, and aqueous thermoreversible gels for drug delivery. Our studies on charge effects on strongly interacting heterogeneous macromolecules, on the other hand, are highly relevant to the understanding of the self-organization of many biological systems. Biological molecules fulfill a wide variety of amazing functions, and the understanding of the relation between their complex structure and their efficiency in performing specific tasks opens the possibility of creating new molecules for innovative applications. Moreover, our studies on peptide amphiphile are motivated by the need of creating new materials for significant medical applications, including nerve repair. We are particularly interested in understanding how different specific interactions, controlled by the synthesis and the environment, influence the properties of the final self-organized material.Educational goals will generate scientists capable of solving challenging and relevant problems for society. A well-balanced gender and ethnicity is kept in the group to prepare for a new generation of scientists. The group participates in local educational programs at the high school level. The group also interacts with scientists in Mexico and France.%%% This award supports theoretical research that will analyze the statistics and thermodynamics of self-associating neutral and charged macromolecules in various environments. In particular, we will determine the structure and phase diagram of solutions of macromolecules with site-specific interactions such as heterogeneous polymers with associating end groups and peptide amphiphile molecules. The study of these macromolecular solutions will lead to the design of new materials. It will also lead to a better understanding of biological materials, with potential applications in drug delivery, bio-adhesion and nerve repair.Educational goals will generate scientists capable of solving challenging and relevant problems for society. A well-balanced gender and ethnicity is kept in the group to prepare for a new generation of scientists. The group participates in local educational programs at the high school level. The group also interacts with scientists in Mexico and France.***

该奖项支持分析各种环境中自缔合中性和带电大分子的统计和热力学的理论研究。 特别是，我们将确定具有位点特异性相互作用的大分子溶液的结构和相图，例如具有缔合端基的异质聚合物和肽两亲分子。 具有缔合端基的异质分子形成胶束和/或簇。 当它们的浓度增加时，簇会在整个系统中扩展，形成凝胶状结构。 这些凝胶的物理性质将根据缔合基团的功能和分子的排除体积进行分析。 我们还将分析聚合物主链上的电荷和环境中的盐对具有强位点特异性吸引力的带电链溶液热力学的影响。 将分析肽两亲分子与圆柱形胶束的结合作为肽浓度和电荷的函数。 我们将在自缔合模型中包含氢键，并将其对胶束结构的影响与偶极子垂直于主链的肽进行比较。 具有相反电荷的两亲性肽的混合物也将被分析为具有特定表面结构的圆柱形胶束的候选者，该胶束由分离驱动的特定表面结构该奖项支持将分析统计数据和肽的理论研究。研究目标是生成新模型来指导合成以及涉及异质大分子和多组分解决方案的新材料的制造。 这些系统能够自组织大量卓越的结构。 我们的结果将有助于设计各种实验系统，包括具有可控粘合性能的非水热可逆凝胶，以及用于药物输送的水性热可逆凝胶。 另一方面，我们对强相互作用异质大分子电荷效应的研究与理解许多生物系统的自组织高度相关。 生物分子具有多种令人惊奇的功能，了解其复杂结构与执行特定任务的效率之间的关系为创造用于创新应用的新分子提供了可能性。 此外，我们对肽两亲物的研究是出于为重要的医学应用（包括神经修复）创造新材料的需要。 我们特别感兴趣的是了解由合成和环境控制的不同特定相互作用如何影响最终自组织材料的特性。教育目标将培养能够解决社会挑战和相关问题的科学家。 该团队保持性别和种族平衡，为新一代科学家做好准备。 该小组参加当地高中水平的教育计划。 该小组还与墨西哥和法国的科学家进行互动。%%% 该奖项支持分析各种环境中自缔合中性和带电大分子的统计和热力学的理论研究。 特别是，我们将确定具有位点特异性相互作用的大分子溶液的结构和相图，例如具有缔合端基的异质聚合物和肽两亲分子。 对这些大分子解决方案的研究将导致新材料的设计。 它还将导致人们更好地了解生物材料，并在药物输送、生物粘附和神经修复方面具有潜在的应用。教育目标将培养能够解决社会挑战性和相关问题的科学家。 该团队保持性别和种族平衡，为新一代科学家做好准备。 该小组参加当地高中水平的教育计划。 该小组还与墨西哥和法国的科学家进行互动。***