Segregation in Multicomponent Macromolecular Systems

多组分大分子系统中的分离

• 批准号: 0414446
• 负责人: Monica Olvera
• 金额: $ 30万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414446&HistoricalAwards=false
• 关键词: Segregation; Multicomponent; Macromolecular; Systems

This award supports theoretical research that will analyze the statistics andthermodynamics of self-associating neutral and charged macromolecules in various environments. In particular, we will determine the structure and phase diagram of solutions of macromolecules with site-specific interactions such as heterogeneous polymers with associating end groups and peptide amphiphile molecules. Heterogeneous molecules with associating end groups form micelles and/or clusters. When their concentration increases the clusters expand over the whole system leading to gel-like structures. The physical properties of these gels will be analyzed as a function of the functionality of the associating groups and the excluded volume of the molecules. We will also analyze the effect of charge on the polymer backbone and of the salt in the environment on the thermodynamics of charged chain solutions with strong site-specific attractions. The association of peptide amphiphile molecules into cylindrical micelles will be analyzed as a function of the concentration and charge of the peptide. We will include hydrogen bonding in the self-associating model and compare its effect on the micelle structure to peptides with dipoles perpendicular to the backbones. Mixtures of peptides amphiphiles of opposite charge will also be analyzed as candidates for cylindrical micelles with specific surface structures driven by the segregation of the This award supports theoretical research that will analyze the statistics and peptides.Research goals are to generate new models to guide the synthesis and fabrication of new materials involving heterogeneous macromolecules and multicomponent solutions. These systems are capable of self-organizing in a large number of remarkable structures. Our results will aid the design of various experimental systems including non-aqueous thermoreversible gels with controllable adhesive properties, and aqueous thermoreversible gels for drug delivery. Our studies on charge effects on strongly interacting heterogeneous macromolecules, on the other hand, are highly relevant to the understanding of the self-organization of many biological systems. Biological molecules fulfill a wide variety of amazing functions, and the understanding of the relation between their complex structure and their efficiency in performing specific tasks opens the possibility of creating new molecules for innovative applications. Moreover, our studies on peptide amphiphile are motivated by the need of creating new materials for significant medical applications, including nerve repair. We are particularly interested in understanding how different specific interactions, controlled by the synthesis and the environment, influence the properties of the final self-organized material.Educational goals will generate scientists capable of solving challenging and relevant problems for society. A well-balanced gender and ethnicity is kept in the group to prepare for a new generation of scientists. The group participates in local educational programs at the high school level. The group also interacts with scientists in Mexico and France.%%% This award supports theoretical research that will analyze the statistics and thermodynamics of self-associating neutral and charged macromolecules in various environments. In particular, we will determine the structure and phase diagram of solutions of macromolecules with site-specific interactions such as heterogeneous polymers with associating end groups and peptide amphiphile molecules. The study of these macromolecular solutions will lead to the design of new materials. It will also lead to a better understanding of biological materials, with potential applications in drug delivery, bio-adhesion and nerve repair.Educational goals will generate scientists capable of solving challenging and relevant problems for society. A well-balanced gender and ethnicity is kept in the group to prepare for a new generation of scientists. The group participates in local educational programs at the high school level. The group also interacts with scientists in Mexico and France.***

该奖项支持理论研究，该研究将分析各种环境中自我关联中性和带电的大分子的统计学和热动力学。 特别是，我们将确定与位点特异性相互作用的大分子溶液的结构和相图，例如与终端组和肽两亲分子的异质性聚合物。 与终端组的异质分子形成胶束和/或簇。 当它们的浓度增加时，簇在整个系统上扩展，导致凝胶状结构。 这些凝胶的物理特性将作为关联基团的功能和分子的排除体积分析。 我们还将分析电荷对聚合物主链和环境中盐的影响对具有较强位点特异性景点的带电链溶液的热力学的影响。 将分析肽两亲分子与圆柱胶束的关联，这是肽的浓度和电荷的函数。 我们将在自缔合模型中包括氢键，并将其对胶束结构的影响与垂直于骨架的偶极子的肽进行比较。 还将分析具有相反电荷的肽两亲物的混合物作为候选圆柱形胶束的候选，该圆柱胶束具有由该奖项隔离的特定表面结构的特定表面结构，该奖项支持了理论研究，该研究将分析统计和肽的研究。研究旨在指导新材料的新模型，以指导新材料的新材料和成分，这些新材料均应构成新材料和远程分析。 这些系统能够在大量出色的结构中进行自组织。 我们的结果将有助于设计各种实验系统，包括具有可控粘合性能的非水热凝胶以及可用于药物输送的水性热凝胶。 另一方面，我们对电荷对强烈相互作用的异质大分子的影响与对许多生物系统的自组织的理解高度相关。 生物分子实现了各种各样的惊人功能，以及对其复杂结构和执行特定任务效率之间关系的理解开辟了为创新应用创建新分子的可能性。 此外，我们对肽两亲动的研究是出于为包括神经修复在内的重要医疗应用创建新材料的需要。 我们特别感兴趣地了解如何受到综合和环境控制的不同特定相互作用，影响最终的自组织材料的特性。教育目标将产生能够解决社会挑战性和相关问题的科学家。 小组中保留了一个平衡的性别和种族，为新一代科学家做准备。 该小组参加了高中一级的当地教育计划。 该小组还与墨西哥和法国的科学家进行互动。%% %%该奖项支持理论研究，该研究将分析各种环境中自缔解中性和带电的大分子的统计和热力学。 特别是，我们将确定与位点特异性相互作用的大分子溶液的结构和相图，例如与终端组和肽两亲分子的异质性聚合物。 对这些大分子溶液的研究将导致新材料的设计。 这也将使人们对生物材料有更好的了解，并在药物输送，生物粘附和神经修复方面的潜在应用。教育目标将产生能够解决社会挑战性和相关问题的科学家。 小组中保留了一个平衡的性别和种族，为新一代科学家做准备。 该小组参加了高中一级的当地教育计划。 该小组还与墨西哥和法国的科学家互动。***