New Synthetic Strategies for the Construction of Complex Molecules: Organoruthenium Based Approaches

构建复杂分子的新合成策略：基于有机钌的方法

基本信息

批准号：
0413076
负责人：
Fred Pigge
金额：
$ 6.2万
依托单位：
University of Missouri-Saint Louis
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-15 至 2005-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0413076&HistoricalAwards=false
关键词：
New Synthetic Strategies Construction Complex

项目摘要

This project is focused on exploiting the unique chemical reactivity of organoruthenium complexes for the stereocontrolled construction of polycyclic heterocyclic compounds related to various alkaloid natural products. The chemistry of eta-6-arene ruthenium(II) complexes will be explored, with the aim of developing novel stoichiometric as well as catalytic synthetic applications. Spirocyclization reactions will be developed and expanded to chiral azaspirocyclic complexes, leading to general synthetic approaches to the spirostaphylotrichins, a subclass of fungal metabolites possessing lipid-lowering activity. Routes to tetrahydroisoquinoline-containing tricyclic ring systems related to a variety of biologically active compounds and the application of the new methodologies to Amaryllidaceae alkaloids, particularly of the crinane and methanomorphanthridine families, will also be explored.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor F. Christopher Pigge, of the Department of Chemistry at the University of Missouri - St. Louis. Professor Pigge's research efforts revolve around the discovery, development, and exploitation of novel reactions effected by compounds containing bonds between carbon and metal atoms. Such organometallic compounds offer promise for efficient approaches for the synthesis of complex organic molecules as well as the preparation of molecules that are virtually inaccessible in the absence of metal atom intervention.

该项目的重点是利用细胞体络合物的独特化学反应性，用于与各种生物碱天然产物有关的多环杂环化合物的立体控制结构。将探索Eta-6-芳烃唯一（II）复合物的化学，目的是开发新型化学计量和催化合成应用。将开发螺旋囊化反应并扩展到手性偶氮螺旋菌配合物，从而导致螺旋体磷酸素的一般合成方法，螺旋体磷脂素是一种具有降低脂质活性的真菌代谢物的亚类。与各种生物活性化合物有关的四氢异喹啉的三环环系统的途径以及新方法在杏仁核生物碱中的应用，特别是在Crinane和甲烷类人类的家庭中，还将探索该奖项。密苏里大学圣路易斯大学化学系。 Pigge教授的研究工作围绕着含有碳和金属原子之间键的化合物产生的新反应的发现，开发和开发。这种有机金属化合物为合成复杂有机分子的合成以及在没有金属原子干预的情况下几乎无法访问的分子的制备提供了有望的有望。