NIRT: Nanohybrids and Nanobiohybrids, Bottom-Up Approach to Nanopatterned Surface Arrays and Application

NIRT：纳米杂化物和纳米生物杂化物，纳米图案表面阵列的自下而上方法及其应用

• 批准号: 0404195
• 负责人: Ulrich Wiesner
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0404195&HistoricalAwards=false
• 关键词: NIRT; Nanohybrids; Nanobiohybrids; Bottom; Up

This Nanoscale Interdisciplinary Research Team (NIRT), cofunded by the Division of Materials Research, the Division of Chemical and Transport Systems, and the Division of Engineering Education and Centers, will develop a "bottom-up" approach based on block copolymer directed thin film assembly of silica nanostructures on silicon and subsequent laser induced melting to generate silicon surface arrays with spacings down to the molecular level (~10 nm). The aim is to understand the dynamics governing creation of these structures, as well as to invent enabling technologies that will allow inexpensive fabrication of large areas of such nanostructures without the use of traditional photolithography. In a first application we will engineer the surfaces towards integration of biomolecules, i.e., to match the natural spacing of an antibody. The team consists of B. Baird, D. Muller, S. Gruner, C. Ober (collaborator), M. Thompson, and U. Wiesner. This work falls into the NSF research and education themes "Nanoscale Structures, Novel Phenomena, and Quantum Control" and (to a lesser extend) "Nanoscale Devices and System Architecture". Intellectual merit of the proposed activityUnderstanding nanostructured thin film formation and nanopillar array formation including the effects of surface wetting and crystal growth in small dimensions will have impact on many areas of nanotechnology. If successful we will enable technologies for the inexpensive fabrication of large areas of such nanostructures without the use of traditional photolithography. This will open up the field to many which currently don't have access to such expensive facilities. Furthermore, engineering the surface structure of a synthetic material towards the molecular architecture of a biomolecule constitutes a powerful paradigm for nanobiotechnology and may lead to completely novel ways of organizing, e.g., proteins on solid substrates for analysis and detection. Cornell is uniquely positioned to make advances in this field and the program will make effective use of Cornell facilities such as the Cornell High Energy Synchrotron Source (CHESS) as well as facilities of the Cornell Center for Materials Research (CCMR) and the Nanobiotechnology Center (NBTC).Broader impacts resulting from the proposed activity Through the collaborative environment with activities ranging from organic synthesis to materials characterization to biology we will promote a way of teaching, training, and learning and thus a unique educational experience for postdoctoral researchers, graduate and undergraduate students not frequently obtained. We will also involve other components of training and development of human resources including the participation of underrepresented groups, efforts to enhance the infrastructure for research and education, and industrial outreach. To this end we intend to work with the excellent and proven platforms provided by the NSF funded Cornell Center for Materials Research (CCMR) and Nanobiotechnology Center (NBTC). In particular, because of the large multiplication effect we will develop Teacher Teaching Teacher (T3) workshops with hands-on lessons that can be brought back into the classrooms, and we will build on a successful collaboration with Simmons College, a primary female college, to introduce students to concepts of nanoscale science and engineering.

这个由材料研究部，化学和运输系统司以及工程教育和中心的划分的纳米级跨学科研究团队（NIRT）将开发一种基于块状共聚物的薄膜组装的“自下而上”方法，该方法的硅纳米结构在硅硅上的硅纳米结构以及硅的硅质降低了米尔克级硅酸盐水平（以米尔克级硅酸盐的水平）（米尔克级硅酸盐），以示硅硅酸盐（米尔克）米尔克（Silicn selferate Surec）（！米布尔式硅酸盐）〜！目的是了解这些结构创建的动态，以及发明启用技术，这些技术将允许在不使用传统光刻志的情况下廉价地制造此类纳米结构的大面积。在第一个应用中，我们将设计朝向生物分子整合的表面，即与抗体的自然间距相匹配。该团队由B. Baird，D。Muller，S。Gruner，C。Ober（合作者），M。Thompson和U. Wiesner组成。这项工作属于NSF研究和教育主题“纳米级结构，新现象和量子控制”，（在较小的扩展中）“纳米级设备和系统体系结构”。提出的纳米结构薄膜形成和纳米阵列形成的拟议活动的智力优点，包括在小维度下表面润湿和晶体生长的影响会影响纳米技术的许多领域。如果成功的话，我们将启用技术，以廉价地制造此类纳米结构的大面积，而无需使用传统的光刻。这将为许多目前无法使用如此昂贵的设施的许多领域开放。此外，在生物分子的分子结构上设计合成物质的表面结构构成了纳米局技术的强大范式，并且可能导致完全新颖的组织方法，例如，在固体底物上蛋白质的蛋白质进行分析和检测。康奈尔（Cornell）的独特位置可以在该领域取得进步，该计划将有效利用康奈尔（Cornell）高能同步器源（Chess）以及康奈尔材料研究中心（CCMR）（CCMR）（CCMR）和纳米生物学技术中心（NANOBIOTOCHOLOGY CENTRAL（NBTC）的材料的特征性活动的特征性活动的特征性活动的范围，促进一种教学，培训和学习的方式，从而为博士后研究人员，研究生和本科生提供独特的教育经验。我们还将涉及人力资源培训和发展的其他组成部分，包括代表性不足的群体的参与，增强研究和教育基础设施的努力以及工业外展。为此，我们打算与NSF资助的康奈尔大学材料研究中心（CCMR）和纳米元素技术中心（NBTC）提供的出色而验证的平台合作。特别是，由于具有较大的乘法效果，我们将通过动手课程开发教师教师（T3）讲习班，可以将其带回教室，我们将与小学女大学的Simmons College成功合作，向学生介绍纳米级科学和工程学的概念。