ADVANCE Fellows Award: Effects of Early Experience on Parental Behavior in Voles

高级研究员奖：早期经验对田鼠父母行为的影响

• 批准号: 0339160
• 负责人: Karen Bales
• 金额: --
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0339160&HistoricalAwards=false
• 关键词: ADVANCE; Fellows; Award; Effects; Early

This project will examine the effects of early social experience onmale parental care in prairie voles (Microtus ochrogaster). Prairie voles are amonogamous, cooperatively breeding species in which males display high levelsof spontaneous parental and alloparental behavior (taking care of infants not their own). However, the principal investigator has previously observed marked differences in paternal behavior as a function of differential handling during the postnatal period. Experiences during the postnatal period and the availability of neuropeptide hormones, including oxytocin (OT) and arginine vasopressin (AVP), may contribute to the expression of positive behaviors toward pups as well. In this project the researcher will study the neurobiology underlying the effects of varying levels of early experience on male alloparental care. Pups will receive different levels of handling during the first week of life. Later variables measured will include alloparental care and anxiety, as well as long-term changes in peptide receptor systems (OT, AVP, and CRH, corticotropin-releasing hormone), mRNA expression for these receptors, and short-term peptide changes in the brain and blood when exposed to a pup. This project will help us to understand the biology of male parenting. Prairie voles are a monogamous species of rodent in which males participate in infant care. This project will investigate the effects of early experiences on later male parental care and its underlying neurobiology.

该项目将研究早期社会经历对草原田鼠（Microtus ochrogaster）雄性亲代照顾的影响。草原田鼠是一夫一妻制、合作繁殖的物种，其中雄性表现出高水平的自发亲代和异亲行为（照顾不是自己的婴儿）。然而，主要研究者之前曾观察到，由于产后差异处理的影响，父亲的行为存在显着差异。产后的经历和神经肽激素（包括催产素（OT）和精氨酸加压素（AVP））的可用性也可能有助于对幼犬表现出积极的行为。在这个项目中，研究人员将研究不同水平的早期经历对男性异亲照顾的影响背后的神经生物学。幼崽在出生的第一周会受到不同程度的对待。后续测量的变量将包括异亲护理和焦虑，以及肽受体系统（OT、AVP 和 CRH、促肾上腺皮质激素释放激素）的长期变化、这些受体的 mRNA 表达以及大脑中的短期肽变化和接触小狗时的血液。这个项目将帮助我们了解男性养育子女的生物学。草原田鼠是一夫一妻制的啮齿动物，雄性参与照顾婴儿。 该项目将研究早期经历对后来男性父母照顾的影响及其潜在的神经生物学。