ADVANCE Fellows Award: Effects of Early Experience on Parental Behavior in Voles

高级研究员奖：早期经验对田鼠父母行为的影响

• 批准号: 0339160
• 负责人: Karen Bales
• 金额: --
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0339160&HistoricalAwards=false
• 关键词: ADVANCE; Fellows; Award; Effects; Early

This project will examine the effects of early social experience onmale parental care in prairie voles (Microtus ochrogaster). Prairie voles are amonogamous, cooperatively breeding species in which males display high levelsof spontaneous parental and alloparental behavior (taking care of infants not their own). However, the principal investigator has previously observed marked differences in paternal behavior as a function of differential handling during the postnatal period. Experiences during the postnatal period and the availability of neuropeptide hormones, including oxytocin (OT) and arginine vasopressin (AVP), may contribute to the expression of positive behaviors toward pups as well. In this project the researcher will study the neurobiology underlying the effects of varying levels of early experience on male alloparental care. Pups will receive different levels of handling during the first week of life. Later variables measured will include alloparental care and anxiety, as well as long-term changes in peptide receptor systems (OT, AVP, and CRH, corticotropin-releasing hormone), mRNA expression for these receptors, and short-term peptide changes in the brain and blood when exposed to a pup. This project will help us to understand the biology of male parenting. Prairie voles are a monogamous species of rodent in which males participate in infant care. This project will investigate the effects of early experiences on later male parental care and its underlying neurobiology.

该项目将研究早期的社会经验在草原田鼠（Microtus ochrogaster）中的玛尔父母护理的影响。草原田鼠是木剂，合作繁殖的物种，男性表现出高水平的父母和同种族的行为（照顾婴儿不是自己的）。但是，主要研究者先前已经观察到父亲行为的明显差异，这是产后差异处理的函数。在产后期间的经验以及包括催产素（OT）和精氨酸加压素（AVP）在内的神经肽激素的可用性可能有助于表达阳性行为对幼犬的表达。在这个项目中，研究人员将研究不同水平的早期经验对男性同种护理的影响。幼崽在生命的第一周将获得不同水平的处理水平。测得的以后变量将包括同种疗法护理和焦虑，以及肽受体系统（OT，AVP和CRH，皮质激素释放激素）的长期变化，这些受体的mRNA表达以及在暴露于幼犬时大脑和血液中的短期肽变化。该项目将帮助我们了解男性育儿的生物学。草原田鼠是一夫一妻制的啮齿动物，男性参与婴儿护理。 该项目将调查早期经验对后来的男性父母护理及其基本神经生物学的影响。