STTR Phase I: Nanoparticle-Assisted Laser Tissue Welding

STTR 第一阶段：纳米粒子辅助激光组织焊接

• 批准号: 0319965
• 负责人: Dennis O'Neal
• 金额: $ 10万
• 依托单位: NANOSPECTRA BIOSCIENCES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319965&HistoricalAwards=false
• 关键词: STTR; Phase; Nanoparticle; Assisted; Laser

This Small Business Technology Transfer (STTR) Phase I project on nanoparticle-assisted laser tissue welding will develop a novel approach for targeting heat generation to a wound site allowing deeper, more uniform welds and a reduction in the extent of tissue damage. Laser tissue welding, the joining of tissues by heat produced from light absorption, has emerged as a commercially and clinically attractive strategy. However, the success of laser tissue welding has been somewhat limited because of (1) generation of superficial welds with poor mechanical integrity due to low optical penetration; and (2) excessive damage to adjacent tissues. In a preliminary study, nanoshells were applied to tissue surfaces and stable welds were formed at laser wavelengths and powers where no significant heating would occur in untreated tissue. Nanoshells are a new class of engineered nanoparticles that can be designed to strongly absorb light in regions where absorption by tissue is minimal and optical penetration is maximal, namely wavelengths in the range of 800-1200 nm. At these wavelengths, light can deeply penetrate tissue with minimal heating and be preferentially absorbed at the nanoshells on the wound surface allowing highly targeted application of the heat required to close the wound.The commercial applications of this project will be in surgical practice for wound closure such as vascular anastamosis, gynecological surgery, thoracic surgery, ocular repair, cartilage repair and liver repair. The core technology may have additional commercial applications in emergency medicine

这个关于纳米颗粒辅助激光组织焊接的小型企业技术转让 (STTR) 第一阶段项目将开发一种新方法，将热量定向到伤口部位，从而实现更深、更均匀的焊接并减少组织损伤的程度。 激光组织焊接，即通过吸收光产生的热量来连接组织，已成为一种在商业和临床上有吸引力的策略。 然而，激光组织焊接的成功在一定程度上受到限制，因为（1）由于光学穿透性低，产生机械完整性差的表面焊缝； (2)邻近组织过度损伤。 在一项初步研究中，将纳米壳应用于组织表面，并在激光波长和功率下形成稳定的焊缝，在未经处理的组织中不会发生明显的加热。 纳米壳是一类新型工程纳米颗粒，可设计为在组织吸收最小且光学穿透最大的区域（即 800-1200 nm 范围内的波长）强烈吸收光。 在这些波长下，光可以以最小的热量深入穿透组织，并优先被伤口表面的纳米壳吸收，从而可以高度有针对性地应用闭合伤口所需的热量。该项目的商业应用将在伤口闭合的外科实践中如血管吻合、妇科手术、胸外科、眼部修复、软骨修复和肝脏修复等。 核心技术可能在急诊医学领域有更多的商业应用