Characterization of a New Gene Required for RNA Interference

RNA 干扰所需的新基因的表征

• 批准号: 0235654
• 负责人: Robert Goldstein
• 金额: $ 39万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0235654&HistoricalAwards=false
• 关键词: Characterization; New; Gene; Required; RNA

RNA interference (RNAi) is the recently-discovered process by which double-stranded RNA silences gene activity. The mechanism by which this occurs is only partially understood, and is of great interest, since RNAi-related phenomena are essential for normal development, because RNAi is now an invaluable tool to biologists studying gene function in diverse organisms, and because of the long-term potential for using RNAi as a therapeutic agent in humans. This project focuses on a new gene required for RNA interference. The sequence of this gene suggests specific, testable hypotheses for how this gene might function in RNAi. The primary goal of this project is to determine how this gene functions. It is expected that this work will make essential contributions to understanding this important pathway. This research project will include training undergraduate students in scientific research, and each undergraduate student will attend an annual conference to present their findings. The principal investigator is a faculty mentor in UNC Chapel Hill's Research Education Support Program, which supports students from under-represented minority groups to gain research experiences and to enroll in Ph.D. programs.

RNA 干扰 (RNAi) 是最近发现的双链 RNA 沉默基因活性的过程。 这种现象发生的机制仅得到部分了解，并且引起了极大的兴趣，因为 RNAi 相关现象对于正常发育至关重要，因为 RNAi 现在是生物学家研究不同生物体中基因功能的宝贵工具，并且因为长期研究使用 RNAi 作为人类治疗剂的术语潜力。 该项目重点研究 RNA 干扰所需的新基因。 该基因的序列提出了关于该基因如何在 RNAi 中发挥作用的具体的、可测试的假设。 该项目的主要目标是确定该基因如何发挥作用。 预计这项工作将为理解这一重要途径做出重要贡献。 该研究项目将包括对本科生进行科学研究培训，每个本科生将参加年度会​​议来展示他们的发现。 首席研究员是北卡罗来纳大学教堂山分校研究教育支持计划的教师导师，该计划支持来自代表性不足的少数群体的学生获得研究经验并攻读博士学位。程序。