QEIB: New Models for the Evolution of Senescence

QEIB：衰老进化的新模型

• 批准号: 0214022
• 负责人: Daniel Promislow
• 金额: $ 10.3万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214022&HistoricalAwards=false
• 关键词: QEIB; New; Models; Evolution; Senescence

Two well-established theories, both developed some fifty years ago, explain why organisms age. However, these models omit ecological and behavioral forces that could influence the evolution of aging. Using mathematical models and computer simulations, this project will develop new models of aging that include ecological and behavior forces. The ultimate goal is to understand currently unexplained aging phenomena, such as why females typically outlive males in most mammals or why some species escape the aging process, and to help predict what sorts of genes should be associated with aging.When complete, these models should give us a much broader understanding of why and how aging occurs in humans and other species, and aid the search for genes that influence aging. In addition to the basic scientific advances that will result from this project, this work will also increase the quality of math science education. This project facilitates a collaboration between the principal investigator-a laboratory researcher who works on aging--and three mathematically-oriented theoreticians. As such, it will greatly enhance opportunities for mathematical training not only for the PI, but also for graduate students and undergraduates at the PI's home institution.

大约五十年前发展了两种良好的理论，解释了生物的年龄。但是，这些模型忽略了可能影响衰老进化的生态和行为力。使用数学模型和计算机模拟，该项目将开发新的衰老模型，包括生态和行为力。最终目标是了解当前无法解释的衰老现象，例如为什么女性在大多数哺乳动物中通常会超过雄性，或者为什么某些物种逃脱了衰老过程，并帮助预测哪种基因应该与衰老相关的基因。完成后，这些模型应该给我们更广泛地了解人类和其他物种的衰老和其他物种的阶段和其他物种的范围，从而对基因和其他物种进行探索，从而对基因和其他物种进行探索。除了该项目将带来的基本科学进步外，这项工作还将提高数学科学教育的质量。该项目促进了从事衰老的实验室研究人员和三位以数学为导向的理论家进行的合作。因此，它将不仅可以为PI，而且还为研究生和本科生在PI家庭机构中提供数学培训的机会。