Coevolution of Marine Sponges and Symbiotic Cyanobacteria and Eubacteria

海洋海绵与共生蓝藻和真细菌的共同进化

• 批准号: 0209329
• 负责人: Robert Thacker
• 金额: $ 17.91万
• 依托单位: University of Alabama at Birmingham
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0209329&HistoricalAwards=false
• 关键词: Coevolution; Marine; Sponges; Symbiotic; Cyanobacteria

ABSTRACTDEB-0209329Dr. Robert W. Thacker of the University of Alabama at Birmingham has been awarded a grant to investigate evolutionary relationships between marine sponges in the family Dysideidae and the microbial symbionts [cyanobacteria ("blue-green algae")] and other bacteria] that live inside these sponges. Many species in the Family Dysideidae produce chemical compounds with anti-viral and anti-cancer properties. Although the porous bodies of these marine sponges can host diverse microbial communities, the role of microbial symbionts in the production of pharmaceutically active compounds remains unclear. A preliminary study by Dr. Thacker suggests that as sponges have evolved and split into distinct species, their microbial communities have evolved in tandem and are specific to each species of sponge. This study will examine several species of Dysidea and related genera from the Western Pacific, Caribbean, and Mediterranean regions. Sponge DNA sequences and microbial DNA sequences will be compared to test the hypothesis that sponges and their symbionts share parallel evolutionary histories. This study will also investigate the placement of the Family Dysideidae into either Order Dendroceratida or Order Dictyoceratida by comparing DNA sequences among members of the Dysideidae and selected sponges from the two orders. In addition, this study will test whether the production of pharmaceutically active compounds is associated with the presence or absence of specific symbionts. This research project will provide a rare, direct comparison of the evolutionary histories of sponges and their symbionts, with an immediate impact on the fields of sponge taxonomy, drug discovery, and host-symbiont coevolution. The project will also provide a greater understanding of the evolutionary histories of sponges and their symbionts, which will accelerate and enrich the search for new anti-viral and anti-cancer drugs. Increased knowledge of these host-microbe interactions will directly impact our understanding of all types of animal-microbe interactions, including those involving humans.

AbstractDeb-0209329dr。阿拉巴马大学伯明翰大学的罗伯特·W·塔克（Robert W. Thacker）被授予赠款，以调查dysideidae家族中海绵与微生物共生体[蓝绿色藻类（“蓝绿色藻类”）和其他生活在这些海绵中的其他细菌的进化关系。 dysideidae家族中的许多物种产生具有抗病毒和抗癌特性的化合物。 尽管这些海洋海绵的多孔体可以容纳多种微生物群落，但微生物共生体在药物活性化合物生产中的作用尚不清楚。 Thacker博士的一项初步研究表明，随着海绵的发展并分为不同的物种，它们的微生物群落已经演变为串联，并且特定于每种海绵。 这项研究将检查西太平洋，加勒比海和地中海地区的几种dysidea及相关属。 将比较海绵DNA序列和微生物DNA序列，以检验海绵及其共生体具有平行进化史的假设。 这项研究还将通过比较dysideidae的成员之间的DNA序列和从两个顺序的选择中进行比较，从而调查了dysideidae家族的放置在树突状或顺序dictyoceratida的阶段。 此外，这项研究将测试药物活性化合物的产生是否与特定共生体的存在或不存在有关。该研究项目将对海绵及其共生体的进化历史进行罕见，直接的比较，并直接影响海绵分类法，药物发现和宿主 - 共生型协调的领域。 该项目还将对海绵及其共生体的进化历史有更深入的了解，这将加速并丰富寻找新的抗病毒和抗癌药物。 对这些宿主微叶相互作用的知识的越来越多将直接影响我们对所有类型的动物 - 微生物相互作用（包括涉及人类）的理解。