U.S.-Germany Cooperative Research: Invigorating the Chemistry of Nitriles: An Exploration of Functionalized Grignard Reagents

美德合作研究：激发腈化学：功能化格氏试剂的探索

• 批准号: 0203145
• 负责人: Fraser Fleming
• 金额: $ 1.92万
• 依托单位: Duquesne University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0203145&HistoricalAwards=false
• 关键词: U.S.; Germany; Cooperative; Research; Invigorating

0203145FlemingThis award supports Fraser Fleming and a student from Duquesne University in a collaboration with Paul Knochel of the Institute for Organic Chemistry at the University of Munich, Germany. The project will focus on a fundamentally different approach to functionalized Grignard reagents with potential for significantly advancing knowledge of bifunctional reagents. Three new amide-containing Grignard reagents will be examined where deprotonatin and silylation is used to mask and unmask the carbonyl group in situ. The collaborative project provides an excellent opportunity for Fleming and the graduate student to pursue new ideas, cultivate creative solutions to significant problems, and learn new skills. The project also provides an opportunity to establish a long-term relationship with the German group with the possibility of continued exchange of students. The students will be able to experience the smaller, more personal environment of Duquesne University, and then perform research at the larger, research-intensive University of Munich, where they will also garner international experience and contacts.

0203145Fleming该奖项支持 Fraser Fleming 和杜肯大学的一名学生与德国慕尼黑大学有机化学研究所的 Paul Knochel 合作。 该项目将重点关注功能化格氏试剂的一种根本不同的方法，该方法有可能显着推进双功能试剂的知识。 将检查三种新的含酰胺格氏试剂，其中使用去质子素和甲硅烷基化来原位掩蔽和暴露羰基。 该合作项目为弗莱明和研究生提供了一个绝佳的机会来追求新想法、培养针对重大问题的创造性解决方案以及学习新技能。 该项目还提供了与德国集团建立长期关系的机会，并有可能继续交换学生。 学生们将能够体验杜肯大学规模更小、更个性化的环境，然后在规模更大、研究密集型的慕尼黑大学进行研究，在那里他们还将获得国际经验和联系。