Investigation of matrix effects in liquid analyses by ICP-OES/MS applying mono-disperse droplet injection

应用单分散液滴注射研究 ICP-OES/MS 液体分析中的基体效应

基本信息

批准号：
156961280
负责人：
Professor Dr. Kay Niemax, since 1/2010
金额：
--
依托单位：
Abteilung 1: Analytische Chemie, Referenzmaterialien
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2009
资助国家：
德国
起止时间：
2008-12-31 至 2011-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/156961280?language=en
关键词：
Investigation matrix effects liquid analyses

项目摘要

Matrix effects known from analyses of liquid samples using inductively coupled plasma-optical emission as well as mass spectrometry (ICP-OES/MS) are investigated experimentally. For this purpose, monodisperse droplets with diameters between ~30 and ~65 µm generated by commercial droplet dispensers are injected into the ICP. The processes of desolvation, atomization and ionization are observed with high temporal resolution recording simultaneously line intensities of atoms and ions belonging to the analytes and the solvent. In particular, the energy transfer between collision partners from the atomized and ionized droplets and the spatial and temporal effects on the local plasma parameters are of interest. The plasma sub-volumes where the interactions occur are imaged with adapted magnification onto the entrance slit of ICCD-spectrometers in order to measure also the spatial expansion of excited atoms and ions from atomized droplets during their passage through the ICP. The investigation will help to understand the physics of matrix effects so that strategies can be developed to reduce or even overcome matrix effects in ICP-OES/MS of liquid samples.In comparison with current nebulizer types, sample introduction by droplet generators has 100% efficiency and is, therefore, suitable for analyses of pL sample volumes. Moreover, it will be investigated whether the periodic introduction of monodisperse droplets can improve the analytical figures of merit of ICP-OES/MS in comparison with current nebulizers where droplets of different sizes are simultaneously injected to the ICP.The project will be carried out in very close collaboration with Prof. Gary M. Hieftje and Dr. George C.Y. Chan (both Department of Chemistry, Indiana University, Bloomington, USA) who are working also on projects for better understanding of matrix effects in ICP-spectrometry of liquid samples in order to optimize the measurement strategy. The main interest of the partners in Bloomington are on macroscopic matrix effects while microscopic processes are in the focus of the ISAS experiments.

使用电感耦合等离子体光发射和质谱 (ICP-OES/MS) 分析液体样品中已知的基质效应，通过实验研究了由商业液滴产生的直径在 ~30 至 ~65 µm 之间的单分散液滴。将分配器注入 ICP 中，通过高时间分辨率同时记录属于原子和离子的线强度来观察去溶剂化、原子化和电离过程。特别是，来自雾化和电离液滴的碰撞伙伴之间的能量传递以及对局部等离子体参数的空间和时间影响是令人感兴趣的。发生相互作用的等离子体子体积通过适当的放大倍数成像。 ICCD 光谱仪的入口狭缝，以便测量雾化液滴在通过 ICP 期间激发的原子和离子的空间膨胀。这项研究将有助于了解基体效应的物理原理，从而制定策略。可以开发用于减少甚至克服液体样品 ICP-OES/MS 中的基质效应。与当前的雾化器类型相比，液滴发生器的样品引入效率为 100%，因此适合 pL 样品体积的分析，将研究与当前将不同尺寸的液滴同时注入到雾化器中的雾化器相比，周期性引入单分散液滴是否可以提高 ICP-OES/MS 的分析品质因数。 ICP。该项目将与 Gary M. Hieftje 教授和 George C.Y. Chan 博士（均为美国布卢明顿印第安纳大学化学系）密切合作，他们也在致力于更好地理解基质效应的项目布卢明顿合作伙伴的主要兴趣是宏观基质效应，而微观过程是 ISAS 实验的重点。