Mechanstic and Exploratory Organic Photochemistry

机械和探索性有机光化学

基本信息

批准号：
0131322
负责人：
Howard Zimmerman
金额：
$ 45.4万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2002
资助国家：
美国
起止时间：
2002-05-01 至 2005-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0131322&HistoricalAwards=false
关键词：
Mechanstic Exploratory Organic Photochemistry

项目摘要

The emphasis of this work is two fold: 1) development of new photochemical reactions and 2) the theoretical as well as experimental understanding of mechanisms of organic photoreactions. On the synthetic organic photochemistry side, several new photochemical rearrangement reactions will be explored as well as some new heterocyclic photochemistry that should lead to a photochemical beta-lactam synthesis. Host-guest or solid state photoreactions which occur within a crystal lattice will continue to be explored. Three different theoretical methods for predicting and modelling organic photochemical processes will also be studied. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Howard E. Zimmerman of the Department of Chemistry at the University of Wisconsin. Dr. Zimmerman will explore new organic photochemical reactions and work to theoretically predict and model the outcomes of existing photochemical reactions. The photochemical reactions studied will serve as the foundation for new synthetic organic procedures and thus have potential applications for the preparation of antibiotics (particularly the heterocyclic photochemistry to be studied) and other pharmaceuticals. Students educated during the course of this work will be broadly trained in theoretical and experimental organic chemistry and preparative photochemistry and gain skills needed by the pharmaceutical industry.

这项工作的重点有两个：1）新光化学反应的发展；2）有机光反应机制的理论和实验理解。在合成有机光化学方面，将探索几种新的光化学重排反应以及一些新的杂环光化学，这些反应将导致光化学β-内酰胺合成。将继续探索晶格内发生的主客体或固态光反应。还将研究用于预测和模拟有机光化学过程的三种不同的理论方法。凭借该奖项，有机和高分子化学项目正在支持威斯康星大学化学系 Howard E. Zimmerman 博士的研究。齐默尔曼博士将探索新的有机光化学反应，并致力于从理论上预测和模拟现有光化学反应的结果。研究的光化学反应将作为新的有机合成过程的基础，因此在抗生素（特别是要研究的杂环光化学）和其他药物的制备方面具有潜在的应用。在这项工作中接受教育的学生将接受理论和实验有机化学和制备光化学方面的广泛培训，并获得制药行业所需的技能。