U.S.-Sweden Cooperative Research: Microfabricated Receptors by Combinatorial Imprinting in Aqueous Media

美国-瑞典合作研究：通过水介质中的组合印迹微加工受体

• 批准号: 0122964
• 负责人: Mingdi Yan
• 金额: --
• 依托单位: Portland State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0122964&HistoricalAwards=false
• 关键词: U.S.; Sweden; Cooperative; Research; Microfabricated

0122964YanThis award supports Mingdi Yan and students from Portland State University in a collaboration with Olof Ramstrom of the Department of Organic Chemistry at the Royal Institute of Technology in Stockholm, Sweden. The project will focus on the difficult tasks of synthesis and use of in aqueous solutions of tailor-made polymeric receptors that are capable of selectively recognizing small differences in ligand structure. New chemistry and fabrication techniques will be applied to molecular imprinting in order to meet the challenge, which is of utmost importance in biological applications. The imprinting chemistry employs reversible, but stable bonds that survive the water environment. The technique of micromoulding in capillary will be used for the synthesis of molecularly imprinted polymers. The same technique will make it possible to accomplish the synthesis of libraries of such polymers that can be screened for optimal imprinting chemistry as well as for biological assays. The long-term goals of the project are to integrate the synthesis and analysis of combinatorial molecularly imprinted polymers on a single chip and to construct multi-analyte sensors based on the microfabricated arrays.

0122964Yan 该奖项支持 Mingdi Yan 和波特兰州立大学的学生与瑞典斯德哥尔摩皇家理工学院有机化学系的 Olof Ramstrom 合作。 该项目将重点关注合成和在水溶液中使用定制聚合物受体的艰巨任务，这些受体能够选择性地识别配体结构的微小差异。 新的化学和制造技术将应用于分子印迹，以应对在生物应用中至关重要的挑战。 压印化学采用可逆但稳定的键，可以在水环境中生存。 毛细管微成型技术将用于分子印迹聚合物的合成。 同样的技术将使得完成此类聚合物库的合成成为可能，这些聚合物可以筛选最佳的印记化学以及生物测定。 该项目的长期目标是将组合分子印迹聚合物的合成和分析集成在单个芯片上，并构建基于微加工阵列的多分析物传感器。