"A Supramolecular Approach to Structure and Reactivity of Organic Molecules"

“有机分子结构和反应性的超分子方法”

• 批准号: 0110655
• 负责人: Nicholas Turro
• 金额: $ 98.3万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2004-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0110655&HistoricalAwards=false
• 关键词: Supramolecular; Approach; Structure; Reactivity; Organic

This project has as its objectives the exploration of supramolecular chemistry with special emphasis on supramolecular photochemistry. One facet of this exploration involves the changes in properties of molecules when they are contained within -- and interact with the interior surface of -- zeolites. An extension of this concept to the area of radical polymerization draws upon the analogy of the chain-end radical being contained within a polymeric vessel. Electron spin resonance and other spectroscopic techniques will be employed to charactersize these radicals and to measure their rate constants of addition to monomers. These investigations will provide knowledge concerning the crucial polymer chain propagating steps, which are of fundamental importance to critical issues in the field of free radical polymerization. Starburst dendrimers will be employed as probes inside DNA and liposome supramolecular containers, giving insight on the ability of some dendrimers to assist in the transfection of DNA into cells.With this Award, the Organic and Macromolecular Chemistry Program continues its support of the research and educational activities of Professor Nicholas J. Turro of Columbia University. Professor Turro's research is in the area of suprameolecular chemistry, wherein smaller molecules are contained within or otherwise interact with larger molecules with attendant alterations in their properties. These principles are likely to have important practical consequenses in the areas of polymer chemistry as well as DNA transfection technologies. In addition, one is able to gain knowledge about the properties of molecules as discrete, individual entities. These studies provide important multidisciplinary educational and training opportunities for graduate and undergraduate students of chemistry as well as for postdoctoral associates.

该项目的目标是对超分子化学的探索，并特别强调超分子光化学。该探索的一个方面涉及分子包含在内部的特性的变化 - 并与 - 沸石的内部表面相互作用。该概念向自由基聚合区域的扩展是基于聚合血管中包含的链端自由基的类比。将采用电子自旋共振和其他光谱技术来对这些激进分子进行特征，并测量其增加单体的速率常数。这些研究将提供有关关键聚合物链传播步骤的知识，这对于自由基聚合领域的关键问题至关重要。 Starburst dendrimers will be employed as probes inside DNA and liposome supramolecular containers, giving insight on the ability of some dendrimers to assist in the transfection of DNA into cells.With this Award, the Organic and Macromolecular Chemistry Program continues its support of the research and educational activities of Professor Nicholas J. Turro of Columbia University. Turro教授的研究是在上分子化学领域，其中较小的分子包含在内部或与较大的分子相互作用，其性质的改变。这些原则可能在聚合物化学和DNA转染技术领域具有重要的实际效果。另外，人们能够获得有关分子作为离散的个体实体的知识。这些研究为化学研究生和本科生以及博士后同事提供了重要的多学科教育和培训机会。