Effects of Tissue Architecture on Vascular Mechanics: Role of the Hierarchical Structure and Constituent Evolution of Elastin

组织结构对血管力学的影响：弹性蛋白的层次结构和成分进化的作用

• 批准号: 0106010
• 负责人: Lisa Pruitt
• 金额: $ 24.99万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0106010&HistoricalAwards=false
• 关键词: Effects; Tissue; Architecture; Vascular; Mechanics

Effects of Tissue Architecture on Vascular Mechanics:ROLE OF THE HIERARCHICAL STRUCTURE AND CONSTITUENT EVOLUTION OF ELASTINThis proposal combines the techniques and approaches of several disciplines, including mechanics, polymer physics, and molecular biology, to study the role of elastin in the arterial wall. Arteries are complex heterogenous structures with profound ability to remodel in response to biochemical and mechanical stimuli. Since arterial diseases like atherosclerosis and aneurysms directly correlate with changes in the amounts of elastin in the vessel wall, it is important to characterize the mechanical properties of arteries with varying amounts of elastin. The project aims to hierarchically link tissue microstructure and biochemical composition of arterial walls to their emergent mechanical behavior. A primary goal of this work is to study the effect of constituents on the structural properties of vessels. The mechanical tests will be used to assess the effects of a changed tissue microstructure on its overall constitutive behavior. In order to link changes in mechanical behavior with alterations in tissue microstructure, structural relationships will be characterized using biochemical methods. The results of this study have broad applicability to vascular mechanics and clinical treatments for arterial diseases.

组织结构对血管力学的影响：弹性蛋白的层次结构和成分进化的作用该提案结合了力学、高分子物理学和分子生物学等多个学科的技术和方法，研究弹性蛋白在动脉壁中的作用。动脉是复杂的异质结构，具有响应生化和机械刺激而重塑的强大能力。由于动脉粥样硬化和动脉瘤等动脉疾病与血管壁弹性蛋白含量的变化直接相关，因此表征具有不同弹性蛋白含量的动脉的机械特性非常重要。该项目旨在将动脉壁的组织微观结构和生化成分与其出现的机械行为分层联系起来。这项工作的主要目标是研究成分对血管结构特性的影响。机械测试将用于评估组织微观结构变化对其整体构成行为的影响。 为了将机械行为的变化与组织微观结构的变化联系起来，将使用生化方法来表征结构关系。这项研究的结果对血管力学和动脉疾病的临床治疗具有广泛的适用性。