Vibrational Spectral Studies

振动光谱研究

• 批准号: 0092922
• 负责人: Prasad Polavarapu
• 金额: $ 30.1万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0092922&HistoricalAwards=false
• 关键词: Vibrational; Spectral; Studies

Prasad L. Polavarapu of Vanderbilt University has support from the Experimental Physical Chemistry Program to continue his spectral studies using vibrational circular dichroism. During the three-year award period, he will undertake the following investigations: a) the elucidation of guest-host interactions for molecules encapsulated in cyclodextrin cavities; b) the determination of absolute configuration of chiral suboxides; c) the determination of structural changes in peptides; d) the determination of the structure of bioactive peptides in membrane environments; e) the structural characterization of peptides that adopt b-hairpin structures; and f) the determination of conformations of chiral herbicides. The principal investigator will also undertake ab initio theoretical calculations in order to fully analyze the experimental observations. These studies will advance knowledge and understanding in a number of fields: chemical, biochemical and environmental. The activities will not only advance scientific knowledge in these areas but also promote training, teaching and learning. One of the more practical impacts of this work will be in the development and design of new herbicides with greater specificity and cost-effectiveness.

范德比尔特大学（Vanderbilt University）的Prasad L. Polavarapu获得了实验性物理化学计划的支持，以使用振动圆形二色性继续其光谱研究。 在三年奖励期间，他将进行以下调查：a）阐明环糊精腔中封装的分子的客座宿主相互作用； b）确定手性亚氧化物的绝对构型； c）确定肽的结构变化； d）确定膜环境中生物活性肽的结构； e）采用B发性结构的肽的结构表征； f）确定手性除草剂的构象。 首席研究者还将进行理论计算，以充分分析实验观察。 这些研究将提高许多领域的知识和理解：化学，生化和环境。 这些活动不仅将在这些领域提高科学知识，还可以促进培训，教学。 这项工作的更实际的影响之一将是对新除草剂的开发和设计，并具有更大的特异性和成本效益。