CAREER: Well-Defined Low-valent Titanium Reductants

职业：明确的低价钛还原剂

• 批准号: 9984776
• 负责人: Folami Ladipo
• 金额: $ 34.8万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9984776&HistoricalAwards=false
• 关键词: CAREER; Well; Defined; Low; valent

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research on the synthesis and characterization of well-defined low valent titanium compounds by Professor Folami Ladipo of the Department of Chemistry at the University of Kentucky. The work involves the synthesis of soluble Ti(II) and Ti(III) complexes supported by calix[4]arene-derived bis(aryloxide) ligands, the elucidation of their structure and the determination of their redox properties. The reaction chemistry of these synthons with alkynes, alkenes, imines and carbonyl compounds will be examined, and correlations established between the steric and electronic properties of the low-valent titanium reductants and their ability to promote chemo-and diastero-selective C-C bond formation. This knowledge will lead to the development of new reductants which operate under well-understood mechanisms.The goal of this research is to produce and characterize new complexes of titanium in low oxidation states which can be used as selective reducing agents in the synthesis of industrially and medically important organic compounds. In addition, some of the titanium reagents themselves are expected to possess useful catalytic properties. Considerable emphasis is being placed on undergraduate education, and inorganic course offerings at the University of Kentucky will be revamped. A cooperative arrangement with Youngstown State University has been established which will bring undergraduate students, particularly women and minorities, into the graduate pipeline.

该无机、生物无机和有机金属化学项目的职业奖支持肯塔基大学化学系 Folami Ladipo 教授对明确的低价钛化合物的合成和表征的研究。 该工作涉及由杯[4]芳烃衍生的双（芳氧基）配体支持的可溶性 Ti(II) 和 Ti(III) 配合物的合成，阐明其结构并测定其氧化还原性质。将检查这些合成子与炔烃、烯烃、亚胺和羰基化合物的反应化学，并建立低价钛还原剂的空间和电子性质及其促进化学和非对映选择性 C-C 键形成的能力之间的相关性。这些知识将导致新还原剂的开发，这些还原剂在充分理解的机制下运行。这项研究的目标是生产和表征低氧化态的新型钛配合物，这些配合物可在工业和工业合成中用作选择性还原剂。医学上重要的有机化合物。此外，一些钛试剂本身预计具有有用的催化性能。肯塔基大学非常重视本科教育，并且将修改无机课程。与扬斯敦州立大学建立了合作安排，将把本科生，特别是女性和少数族裔学生纳入研究生队伍。