CAREER: Synthetic Methodologies Based on Novel SET-Induced Cleavage in Hydroxyalkyl Dithianes

职业：基于羟烷基二噻烷中新型 SET 诱导裂解的合成方法

• 批准号: 9876389
• 负责人: Andrei Kutateladze
• 金额: $ 34.32万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9876389&HistoricalAwards=false
• 关键词: CAREER; Synthetic; Methodologies; Based; Novel

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Andrei G. Kutateladze of the Department of Chemistry and Biochemistry at the University of Denver. His research is aimed at designing improved organic synthetic methods based on electron transfer- induced cleavage of substituted alpha-hydroxyalkyl dithianes. These dithianes (cyclic compounds containing two sulfur atoms) are used to protect carbonyl groups (C=O) during the synthesis of complex organic compounds, and have the novel property of being readily removed with light.The PI believes strongly in integrating education and research, and involves students in a wide variety of research activities including synthesis, photochemistry and photophysics, nuclear magnetic resonance, materials science, theoretical chemistry, and computer programming. His educational activities under this grant include developing one freshman/sophomore level organic course and two advanced courses, utilizing multimedia, computer simulation/animation, and molecular modeling. The PI encourages his graduate students to participate in local high school Science Fairs, and will participate in a departmental summer research program for area high school chemistry teachers.

有了这个职业奖，有机和大分子化学计划支持丹佛大学化学和生物化学系的安德烈·G·库特塔德兹博士的工作。 他的研究旨在设计基于电子转移诱导的替代α-羟基烷基二硫代烷的裂解的改进有机合成方法。 These dithianes (cyclic compounds containing two sulfur atoms) are used to protect carbonyl groups (C=O) during the synthesis of complex organic compounds, and have the novel property of being readily removed with light.The PI believes strongly in integrating education and research, and involves students in a wide variety of research activities including synthesis, photochemistry and photophysics, nuclear magnetic resonance, materials science, theoretical chemistry, and计算机编程。 他在这笔赠款下的教育活动包括开发一个新生/大二水平的有机课程和两个高级课程，利用多媒体，计算机模拟/动画和分子建模。 PI鼓励他的研究生参加当地的高中科学博览会，并将参加一项针对地区高中化学老师的部门夏季研究计划。