Mechanisms of Nucleic Acid Oxidation

核酸氧化机制

• 批准号: 9818484
• 负责人: Cynthia Burrows
• 金额: $ 41.43万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9818484&HistoricalAwards=false
• 关键词: Mechanisms; Nucleic; Acid; Oxidation

With this renewal award the Organic and Macromolecular Chemistry Program continues its support for the work of Dr. Cynthia J. Burrows in the Department of Chemistry at the University of Utah. The research extends earlier studies on nickel complex mediated oxidation of DNA by persulfuric acid, to the oxidation of nucleobases in DNA and RNA structures by a variety of oxidizing agents and transition metal complexes. Of particular interest is the oxidation of guanine and further reactions of its common oxidation product, 7,8-dihydro-8-oxoguanine. Results of these studies will have applications in toxicology, polynucleic acid structure, and nucleic acid-protein interactions. The oxidation and subsequent degradation of DNA is implicated in the aging process and in the operation of a number of drugs, for example those used in the treatment of cancer. Students trained on this project will gain valuable experience in bioorganic and bioinorganic chemistry useful in a number of biotechnology fields.

有了这一续签奖，有机和大分子化学计划将继续对犹他大学化学系Cynthia J. Burrows博士的工作支持。 该研究将通过过硫酸对镍复合物介导的DNA氧化的早期研究扩展到通过多种氧化剂和过渡金属复合物通过多种氧化剂和RNA结构中核碱基氧化的氧化。 特别令人感兴趣的是鸟嘌呤的氧化及其常见氧化产物的进一步反应，7,8-二氢-8-氧烷氨酸。 这些研究的结果将在毒理学，多核酸结构和核酸 - 蛋白质相互作用中应用。 DNA的氧化和随后降解与衰老过程和许多药物的运行有关，例如用于治疗癌症的药物。 接受该项目培训的学生将获得在许多生物技术领域有用的生物有机和生物无机化学方面的宝贵经验。