Japan JSPS Program: Enantioselective Total Synthesis of (+)- Catharanthine

日本JSPS计划：( )-长春质的对映选择性全合成

• 批准号: 9803688
• 负责人: Eric Zylstra
• 金额: $ 0.3万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2000-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803688&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Enantioselective; Total

Zylstra 9803688 This award supports a 24 month Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Dr. Eric Zylstra at the University of Tokyo in Japan. Dr. Zylstra will work with Dr. Tohru Fukuyama, Professor, Faculty of Pharmaceutical Sciences, University of Tokyo on a research project entitled "Enantioselective Total Synthesis of Vinblastine." The proposed research will provide a direct, efficient route to the antitumor drug vinblastine. Although this compound has a long history of use in chemotherapy, its structural complexity hinders the preparation of analogs. One commonly chosen synthetic strategy toward vinblastine is the coupling of catharanthine or a catharanthine-like precursor with the structurally-related compound vindoline. Investigations will be undertaken on the usefulness of some novel palladium methodology for assembling the vinblastine skeleton. This should lead to development of a more direct, efficient route to its synthesis making it, and structurally similar analogs, more readily available for the preparation of new, more potent vinblastine analogs. ***

Zylstra 9803688 该奖项为日本东京大学的 Eric Zylstra 博士提供为期 24 个月的日本学术振兴会 (JSPS) 博士后奖学金。 Zylstra 博士将与东京大学药学院教授 Tohru Fukuyama 博士合作开展一项名为“长春花碱的对映选择性全合成”的研究项目。 拟议的研究将为抗肿瘤药物长春花碱提供直接、有效的途径。 尽管该化合物在化疗中使用已有悠久的历史，但其结构复杂性阻碍了类似物的制备。 一种常用的长春花碱合成策略是将长春花碱或长春花碱类前体与结构相关的化合物长春花碱偶联。 将研究一些新颖的钯方法用于组装长春花碱骨架的有用性。 这应该会导致开发一种更直接、更有效的合成途径，使其和结构相似的类似物更容易用于制备新的、更有效的长春花碱类似物。 ***