U.S.-Germany Cooperative Research: Recruitment of Neuromodulatory Neurons during Behavior

美德合作研究：行为过程中神经调节神经元的招募

• 批准号: 9726330
• 负责人: Richard Levine
• 金额: $ 0.54万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-15 至 2001-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726330&HistoricalAwards=false
• 关键词: U.S.; Germany; Cooperative; Research; Recruitment

This award supports Dr. John Levine and a post doctoral student from the University of Arizona in a collaboration with Hans Joachim Pfl¼ger of the Department of Neurobiology at the Free University of Berlin. The collaboration will determine the neuronal pathways through which identified octopaminergic modulatory neurons are recruited during well- characterized behaviors including crawling, walking, flight, kicking, and ekdysis. In addition the U.S. and German groups will determine how the patterns of modulatory neuron recruitment are modified to accommodate behavioral changes at metamorphosis. Modulatory neurons release substances, including biogenic amines or neuropeptides that influence the function of the central and peripheral nervous systems profoundly. Although there is much information regarding the effects of modulatory substances on target neurons or muscles, relatively little is understood about the neuronal circuits that activate the modulatory neurons. This collaboration will use two complementary and well- characterized insect model systems to investigate the mechanisms involved in recruitment of those neurons.

该奖项支持亚利桑那大学的 John Levine 博士和一名博士后与柏林自由大学神经生物学系的 Hans Joachim Pflüger 合作，确定已识别的章鱼胺能调节神经元的神经元通路。此外，美国和德国的研究小组将确定如何修改调节性神经募集模式以适应行为变化。尽管有很多关于调节物质对目标神经元或肌肉的影响的信息，但对神经元的了解相对较少。这项合作将使用两个互补且特征良好的昆虫模型系统来研究招募这些神经元的机制。