Upgrade of the UW Chemistry Department NMR Facility

华盛顿大学化学系核磁共振设施升级

• 批准号: 9710008
• 负责人: Paul Hopkins
• 金额: $ 21.2万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9710008&HistoricalAwards=false
• 关键词: Upgrade; UW; Chemistry; Department; NMR

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Major Research Instrumentation (MRI) Program will assist the Department of Chemistry at University of Washington in the purchase of a 500 MHz NMR spectrometer. This equipment will enhance research in a number of areas including exchange coupling in transition metal polyhydrides; helix/coil transitions, cold-induced helix unfolding; energetics and mechanisms of reductive elimination reactions; sequence determinants of the folding of recognition domains; dynamics of local angular motions of specific groups in DNA; determination of protein structure and dynamics; and structure elucidation for lesion sites in damaged DNA. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.

该奖项由化学研究仪器和设施 (CRIF) 计划以及主要研究仪器 (MRI) 计划授予，将协助华盛顿大学化学系购买 500 MHz NMR 波谱仪。该设备将加强多个领域的研究，包括过渡金属多氢化物的交换耦合；螺旋/线圈转变，冷诱导螺旋展开； 还原消除反应的能量学和机制；识别域折叠的序列决定因素； DNA 中特定基团的局部角运动动力学；蛋白质结构和动力学的测定；以及受损 DNA 中损伤位点的结构阐明。 核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具。 它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于进行前沿研究的化学家来说，获得最先进的核磁共振波谱分析至关重要。这些 NMR 研究的结果可用于聚合物、催化和生物学等领域。