Reduction of Polyhalogenated Alkanes in the Environment: Verification of Model Systems

减少环境中的多卤代烷烃：模型系统的验证

• 批准号: 9709364
• 负责人: Judith Perlinger
• 金额: $ 1.8万
• 依托单位: Michigan Technological University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9709364&HistoricalAwards=false
• 关键词: Reduction; Polyhalogenated; Alkanes; Environment; Verification

Professor Judith Perlinger, Department of Chemistry, Michigan Technological University, is supported by the Organic and Macromolecular Program of the Chemistry Division under a Research Planning Grant to study the reduction of halogenated alkenes under environmental conditions. The goal of this project is to establish one-electron reduction as the rate determining step in the reduction of halogenated alkanes by naphthoquinone, mercaptojuglone and iron porphyrins. Electron transfer rates of these model systems will be analyzed in terms of Marcus theory to develop a more global reactivity model applicable to natural systems. Naturally occuring organic and iron-sulfur containing species will be identified and their rates of reduction of polyhalogenated alkanes compared to those of the model systems to assess their usefulness in detoxifying polyhalogenated alkanes. Given the timely nature of the problem, a Research Planning Grant at this point in Professor Perlinger's career will facilitate completion of the preliminary studies needed for a competitive proposal. The release of halogenated compounds into the environment creates the need to detoxify these reagents under natural conditions. Reduction to more benign products occurs under laboratory conditions, but the chemistry under environmental conditions is not known. Systematic studies of model electron transfer systems will be performed to identify the rate controlling reaction step, and the data used to develop a more global reactivity model. Naturally occurring reductants will be identified, and their usefulness as reductants of polyhalogenated compounds under environmental conditions assessed by means of the developed reactivity model.

密歇根理工大学化学系的 Judith Perlinger 教授得到了化学系有机和高分子项目的研究计划资助的支持，研究环境条件下卤代烯烃的还原。 该项目的目标是建立单电子还原作为萘醌、巯基胡桃酮和铁卟啉还原卤代烷烃的速率决定步骤。 这些模型系统的电子转移速率将根据马库斯理论进行分析，以开发适用于自然系统的更全局的反应性模型。 将鉴定天然存在的有机物质和含铁硫物质，并将其多卤代烷烃的还原率与模型系统的还原率进行比较，以评估它们在多卤代烷烃解毒方面的有用性。 鉴于该问题的及时性，佩林格教授职业生涯中此时的研究计划补助金将有助于完成竞争性提案所需的初步研究。 卤代化合物释放到环境中需要在自然条件下对这些试剂进行解毒。 在实验室条件下会还原成更良性的产物，但环境条件下的化学反应尚不清楚。 将进行模型电子转移系统的系统研究，以确定速率控制反应步骤，以及用于开发更全局反应模型的数据。 将鉴定天然存在的还原剂，并通过开发的反应性模型评估它们在环境条件下作为多卤化合物还原剂的有用性。