CAREER: Transition Metal Initiators for the Synthesis of Well-Defined Polypeptides

职业：用于合成明确多肽的过渡金属引发剂

• 批准号: 9701969
• 负责人: Timothy Deming
• 金额: $ 8万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9701969&HistoricalAwards=false
• 关键词: CAREER; Transition; Metal; Initiators; Synthesis

Professor Deming's research focuses on the use of transition metal complexes as initiators for the synthesis of well-defined polypeptides. Polymerization of alpha-amino acid N-carboxyanhydrides using various Cu, Ni, Pd and Zn complexes provides a nonbiological alternative for the preparation of polypeptides, including block co-polymers expected to display properties rivaling those of naturally occurring structural proteins. Light scattering, viscometry, and x-ray diffraction, as well as mechanical testing and processing, will permit characterization and evaluation of the materials produced. Professor Deming will introduce a biomaterials curriculum at the undergraduate and graduate levels, presenting core macromolecular courses and covering biopolymer synthesis and the structure, dynamics, and processing of biomaterials. With this CAREER award, the Synthetic Organic Program supports the research and educational activities of Professor Timothy J. Deming of the Materials and Chemistry Departments at the University of California, Santa Barbara. Professor Deming's research focuses on the use of transition metal complexes as initiators for the formation of well-defined polypeptides, specifically targeting materials which are expected to mimic naturally occurring structural polypeptides such as spider silk and collagen. These materials are of particular interest because of their excellent physical properties, biocompatability, biodegradability, and potential for biomedical applications. Professor Deming's educational activities are focused on the development of a new curriculum that consists of a core sequence of courses covering the science of large molecules and additional courses focused on biological materials. This training, at both the undergraduate and graduate levels, will be complemented by student involvement in biomaterials research programs, affording a unique opportunity to participate in multidisciplinary research and laying the groundwork for effective future collaborative research efforts.

戴明教授的研究重点是使用过渡金属配合物作为合成明确多肽的引发剂。 使用各种 Cu、Ni、Pd 和 Zn 络合物聚合 α-氨基酸 N-羧酸酐为制备多肽提供了一种非生物替代方案，包括预期表现出与天然存在的结构蛋白的性质相媲美的嵌段共聚物。 光散射、粘度测定和 X 射线衍射以及机械测试和加工将允许对所生产的材料进行表征和评估。 戴明教授将为本科生和研究生引入生物材料课程，呈现核心高分子课程，涵盖生物聚合物合成以及生物材料的结构、动力学和加工。 凭借这一职业奖，合成有机项目支持加州大学圣巴巴拉分校材料和化学系蒂莫西·J·戴明教授的研究和教育活动。 戴明教授的研究重点是使用过渡金属配合物作为形成明确多肽的引发剂，特别是针对有望模仿天然存在的结构多肽（例如蜘蛛丝和胶原蛋白）的材料。 这些材料因其优异的物理性能、生物相容性、生物降解性和生物医学应用潜力而受到特别关注。 戴明教授的教育活动重点是开发新课程，该课程由涵盖大分子科学的核心课程和专注于生物材料的附加课程组成。 本科生和研究生级别的培训将辅以学生参与生物材料研究项目，提供参与多学科研究的独特机会，并为未来有效的合作研究工作奠定基础。