Sex-specific epigenetic atlas across lifespan

整个生命周期的性别特异性表观遗传图谱

• 批准号: DP240102155
• 负责人: Prof Nir Eynon
• 金额: $ 41.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102155
• 关键词: Sex; specific; epigenetic; atlas; across

This project aims to uncover sex-specific molecular marks that either predict or mediate healthy ageing across multiple tissues in humans. This project expects to generate new knowledge of cellular heterogeneity and epigenetic control of phenotype and healthy ageing. Further, we anticipate to uncover age-associated changes that differ between males and females, an area of chronic research under representation. These outcomes will lead to a comprehensive understanding of fundamental biological processes across lifespan, and our development of an open access atlas will underpin evidence-based personalised health strategies to keep Australians healthier for longer.

该项目旨在揭示性别特异性的分子标记，这些分子标记可以预测或介导人类多种组织中健康衰老。该项目预计将产生有关细胞异质性和对表型和健康衰老的表观遗传控制的新知识。此外，我们预计将发现与男性和女性之间不同的年龄相关变化，这是一个正在代表的慢性研究的领域。这些结果将使人们对整个生命周期的基本生物学过程有全面的了解，而我们开放的通道地图集则将基础基于证据的个性化健康策略，以使澳大利亚人更长的健康状况更长。