Engineering HIV virus-like-particles (VLPs) for improved Env antigenicity and neutralizing antibody responses.

工程化 HIV 病毒样颗粒 (VLP)，以提高 Env 抗原性和中和抗体反应。

• 批准号: 403720
• 负责人: Mann Jamie F
• 金额: $ 39.29万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=403720&lang=en
• 关键词: B Cells; Envelope Glycoprotein; Hiv; Immunogenicity; Lymph Nodes; Vaccine; Virus-Like-Particle

HIV-1 is the etiological agent behind the global HIV epidemic.It is acknowledged that an efficacious anti-HIV vaccine remain the best hope for eliminating the HIV-1 epidemic. However, the failure to produce effective vaccine immunogens and the inability o

HIV-1是全球HIV流行的病原体。众所周知，有效的抗HIV疫苗仍然是消除HIV-1流行的最大希望。然而，未能生产出有效的疫苗免疫原并且无法生产出有效的疫苗免疫原。