Neural Binding and Promotion of Neurite Outgrowth by Cytotactin/Tenascin Domains

细胞趋化素/腱生蛋白结构域的神经结合和促进神经突生长

• 批准号: 9422111
• 负责人: Kathryn Crossin
• 金额: $ 33.51万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9422111&HistoricalAwards=false
• 关键词: Neural; Binding; Promotion; Neurite; Outgrowth

9422111 Crossin The development of the nervous system is dependent upon coordinated interactions among specialized cells including neurons, glia and other types of support cells, and of these cells with surrounding extracellular matrix (ECM) proteins. Cell attachment and migration as well as neurite outgrowth, guidance, and fasciculation are all affected by interaction of cells with components of the ECM during both development and regeneration. This research focuses on analyzing a specific ECM protein, called cytotactin/tenascin, and its interaction with nerve cells and with other matrix components. This molecule is particularly interesting because it has been shown to promote cell growth under some conditions and to inhibit growth under others. The results of these studies should reveal mechanisms of neurite outgrowth promotion by molecules present in regenerating nerves and also promise to shed light on general mechanisms of cellular guidance and repair occurring during development and regeneration of the nervous system.

9422111越过神经系统的发展取决于包括神经元，神经胶质和其他类型的支持细胞以及这些细胞周围细胞外基质（ECM）蛋白质的特殊细胞之间的协调相互作用。细胞的附着和迁移以及神经突生长，引导和偶像都受到在发育和再生过程中细胞与ECM成分的相互作用的影响。这项研究的重点是分析一种称为细胞毒素/替纳斯蛋白的特定ECM蛋白，及其与神经细胞以及其他基质成分的相互作用。 该分子特别有趣，因为它已被证明可以在某些条件下促进细胞生长，并抑制其他条件下的生长。 这些研究的结果应揭示神经中存在的分子促进神经突生长的机制，并有望阐明在神经系统发展和再生过程中细胞引导和修复的一般机制。