ABR: Ecology and Genetics of Microbial Evolution

ABR：微生物进化的生态学和遗传学

• 批准号: 9421237
• 负责人: Richard Lenski
• 金额: $ 26万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9421237&HistoricalAwards=false
• 关键词: ABR; Ecology; Genetics; Microbial; Evolution

9421237 Lensky Microorganisms perform various ecological functions that may be either beneficial (e.g., decomposition of wastes) or deleterious (e.g., pathogens of humans and crops), depending on the particular species and environmental context. Much is known about the biochemistry and molecular genetics of certain microorganisms, but very little is known about the population dynamics of microorganisms and how various ecological and genetic factors affect microbial evolution. The proposed research seeks to identify and quantify important ecological and genetic processes that may influence the dynamics of microbial populations. There are two major objectives (1) To model mathematically the dynamics of host-pathogen interactions in order to understand the ecological and evolutionary forces that shape virulence, especially in relation to specific modes of pathogen transmission and (2) To quantify experimentally the genetic variation in bacterial populations for such important phenotypic traits as competitiveness and cell size, including the contribution of deleterious mutations, substitution of favorable mutations, and balanced polymorphisms to this variation.

9421237 Lensky微生物具有各种生态功能，这些生态功能可能是有益的（例如废物的分解）或有害的（例如，人类和农作物的病原体），具体取决于特定的物种和环境环境。 关于某些微生物的生物化学和分子遗传学知之甚少，但对微生物的种群动态以及各种生态和遗传因素如何影响微生物进化知之甚少。 拟议的研究旨在识别和量化可能影响微生物种群动态的重要生态和遗传过程。 有两个主要目标（1）可以在数学上对宿主 - 病原体相互作用的动态进行建模，以了解塑造毒力的生态和进化力，尤其是与病原体传播的特定模式和（2）相关的，以实验量化细菌种群的遗传变异，用于竞争性竞争性和替代表型，包括典型典型的繁殖，包括繁殖的繁殖，包括繁殖的繁殖，贡献了杂物，这种变化的多态性。