NSF Young Investigator: Host-Guest Molecular Recognition in the Gas-Phase

NSF 青年研究员：气相中的主客体分子识别

• 批准号: 9357118
• 负责人: David Dearden
• 金额: $ 6.25万
• 依托单位: University of Texas at Arlington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-15 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9357118&HistoricalAwards=false
• 关键词: NSF; Young; Investigator; Host; Guest

This NSF Young Investigator Award from the Organic Dynamics Program supports the work of Professor Dearden at the University of Texas at Arlington. Intrinsic molecular recognition properties of crown ethers and related ligands for metal and molecular ions will be investigated in the gas phase using ion cyclotron resonance and tandem mass spectrometric techniques. Use will be made of the matrix-assisted laser desorption and electrospray ionization techniques. The specific areas concern (a) the identification of crown ether / alkali metal host-guest systems, (b) singly-charged alkaline earth monohalides and ammonium cations, (c) chiral host-guest systems, (d) biological ionophores, enzyme / substrate systems, and cyclodextrins. %%% With this NYI award Professor David D. Dearden's will conduct gas phase studies to determine both the intrinsic factors and the role of solvation in governing molecular recognition. By eliminating the effects arising from solvents and counterions, the interaction between hosts and guests can be probed directly. This work will make use of matrix-assisted laser desorption and electrospray ionization techniques, enabling a greatly extended range of masses detectable by mass spectrometry. This work aims to develop chemical and spectroscopic probes to determine 3-dimensional ion structures.

这项NSF年轻调查员奖获得了有机动力学计划，该奖项支持德克萨斯大学阿灵顿分校的Dearden教授的工作。金属和分子离子的冠状醚和相关配体的固有分子识别特性将在气相中使用离子回旋共振和串联质谱技术研究。使用基质辅助激光解吸和电喷雾电离技术。特定区域涉及（a）识别冠醚 /碱金属宿主 - 宿主系统，（b）单一含有碱性的碱性土单链烷和铵阳离子，（c）手性宿主 - 宿主 - 环系统，（d）生物学离子载体，酶 /底物系统和环脱糖剂。 %% %%与NYI奖教授戴维·D·迪尔登（David D. Dearden）将进行气期研究，以确定内在因素和溶剂化在治理分子识别中的作用。通过消除溶剂和柜台产生的影响，可以直接探测主机与客人之间的相互作用。这项工作将利用基质辅助激光解吸和电喷雾电离技术，从而实现了可通过质谱检测到的大量扩展质量。这项工作旨在开发化学和光谱探针以确定三维离子结构。