Filter Properties of Chemoreceptor Cells

化学感受器细胞的过滤特性

• 批准号: 9222774
• 负责人: Jelle Atema
• 金额: $ 33.08万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-15 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9222774&HistoricalAwards=false
• 关键词: Filter; Properties; Chemoreceptor; Cells; Filter; Properties; Chemoreceptor; Cells

9222774 Atema The way in which sensory receptors process rapid changes of stimulus over time has not been studied much in chemical reception (smell and taste), where the emphasis has been on molecular recognition. Yet complex and dynamic odors characterize the natural environment, and are likely to be very important to how the brain integrates chemosensory signals into appropriate behavior. This work develops novel electrochemical measuring techniques for investigating the spatial and temporal resolution of olfactory receptors on the very accessible model system of the antenna of marine crustaceans. A new tightly-controlled stimulus delivery technology allows a variety of stimulus parameters to be used while measuring the magnitude and reliability of response parameters, looking at effects such as excitation and adaptation patterns. The data will be incorporated into a model of chemosensory dynamics, and extended in studies on receptor development and central coding. This work will have impact beyond chemosensory neurobiology into areas of diagnostic tests for smell and taste performance for the food industry as well as medicine, and to the potential biotechnological development of underwater chemosensing robotic devices for ecology and for fisheries exploitation. ***

9222774 ATEMA的感觉受体在化学接收（气味和味道）中尚未对刺激的快速变化进行处理的方式，在这种情况下重点是分子识别。 然而，复杂而动态的气味是自然环境的特征，对于大脑如何将化学感信号整合到适当的行为中可能非常重要。 这项工作开发了新型的电化学测量技术，用于研究嗅觉受体在海洋甲壳类动物天线非常易于可访问的模型系统上的空间和时间分辨率。 一种新的紧密控制的刺激输送技术允许在测量响应参数的幅度和可靠性的同时使用各种刺激参数，以查看诸如激发和适应模式之类的效果。 数据将纳入化学感应动力学模型，并扩展到有关受体开发和中央编码的研究中。 这项工作将影响化学感应神经生物学以外的影响，进入诊断性测试的食品工业以及药物的气味和味觉表现，以及在水下化学化学启用机器人方面的潜在生物技术发展，用于生态学和渔业开发。 ***